ZO Skin Health Launches an Upgraded G Factor Serum with Biosynthetic Growth Factors for Medical-Institution-Only Skincare

ZO Skin Health, a medical-institution-only skincare brand developed from the dermatological research of practicing dermatologist Dr. Zein Obagi, has renewed its G Factor Serum, a product focused on the skin’s foundation, the extracellular matrix. The upgraded serum contains biosynthetic growth factors and is designed to help skin look youthful and healthy. ZO Skin Health was created in 2007 to bring Dr. Obagi’s more than 40 years of clinical experience and dermatological knowledge into home skincare. Guided by the belief of providing beautiful, healthy skin to people around the world, Dr. Obagi has studied skin mechanisms in depth and earned strong support from clients including Hollywood stars and top models. The brand has since been adopted by many medical institutions and continues to develop advanced home-care products based on clinical cases and the latest dermatological science. The next-generation G Factor Serum is the result of more than 18 years of aging-care research. Dr. Obagi previously transformed skincare through retinol-based protocols, and this new development focuses on thinning skin, a common age-related concern. As skin becomes thinner, it becomes more vulnerable to external irritation, more prone to wrinkles, and less able to maintain elasticity. G Factor Serum applies biotechnology and growth-factor research to support the appearance of skin thickness, elasticity, smoothness, and flexibility. The “G Factor” in G Factor Serum refers to Growth Factor. Developed around the concept of increasing the density of aging skin, the gel serum addresses multiple aging concerns and contains biosynthetic growth factors that act similarly to human-derived growth factors. With age, both the epidermis and dermis weaken: keratinocyte proliferation decreases, turnover slows, old keratin accumulates, and the proliferative ability of basal-layer cells declines, reducing overall epidermal thickness. Collagen production also falls and fiber structures deteriorate, causing the dermis, the skin’s foundation, to lose volume. As fullness decreases, skin becomes more prone to sagging and expression lines. According to ZO Skin Health, the renewed G Factor Serum supports hydration, hyaluronic acid, and collagen production to help create a plump, firm, dense-looking complexion. By adding advanced biosynthetic growth factors, the product targets the skin’s natural thickness and elasticity. The company says Japanese consumers with high skincare literacy place the greatest importance on visible effectiveness, and the renewed serum reflects ZO Skin Health’s latest research and medical-grade skincare expertise. Connie Peev, Education & Training Manager APAC, stated that G Factor Serum is the brand’s flagship aging-care serum, developed by ZO Skin Health’s R&D team with the latest scientific insights. More than 18 years before exosomes and growth factors became major topics in cosmetics, ZO’s R&D team had already been researching them. Growth factors, which act as command signals that initiate key processes for cellular repair and rebuilding, were considered especially promising, though cosmetic applications posed challenges in formulation stability and safety. The next-generation G Factor Serum was developed after identifying ingredients that can provide effects similar to human-derived growth factors while also offering reliability, stability, and consistent supply. Key points include the addition of biosynthetic growth factors to support the skin’s foundation; the selection of five types of biosynthetic growth factors from hundreds of candidates, inspired by the balance of multiple growth factors in human placenta; and the continued use of ingredients popular in the original formula, including plant- and enzyme-derived growth-factor-like components, a peptide sometimes referred to as a topical botulinum-toxin-like ingredient, and ZO’s proprietary ZPRO technology to support the intercellular matrix and skin volume. Product overview: G Factor Serum, 30 mL, suggested retail price 26,400 yen including tax, launching Tuesday, May 12. The product is designed to deliver moisture to skin that feels less firm and resilient, provide firmness and elasticity, create a plump and bouncy skin impression, refine surface texture, and support a lively-looking complexion. It is alcohol-free and retinol-free. Use one to two pumps morning and evening on clean, dry skin. ZO Skin Health also released findings from a survey of 732 women in their 30s to 50s across Japan who are interested in anti-aging. The survey found a significant gap between consumer understanding of aging skin and dermatological facts. Many respondents recognized surface-level changes such as sagging-related wrinkles, slower turnover, and reduced collagen and elastin, while fewer understood structural changes such as weakening of the skin’s supporting foundation, reduced dermal density, and thinning of the epidermis. Familiar ingredients such as vitamin C and hyaluronic acid were relatively well understood, while newer terms such as exosomes and PDRN were often recognized by name only. Expectations for growth factors included supporting the skin’s foundational structure and increasing density and plumpness, but many respondents still said they did not understand them well. The survey suggests a growing need for comprehensive care focused on skin structure rather than only localized correction. ZO Skin Health is a medical skincare brand created by internationally renowned practicing dermatologist Dr. Zein Obagi. Based on the belief of providing beautiful, healthy skin to everyone worldwide, the brand aims to address the root causes of skin concerns. It offers comprehensive solutions for maintaining healthy skin regardless of age, ethnicity, skin condition, or skin type, and is now sold in more than 100 countries. Through skincare professionals, ZO Skin Health pursues healthier, more beautiful skin through three steps: Getting Skin Ready, Prevent + Correct, and Protect. ZO Skin Health products are sold exclusively through medical institutions and should be used after consultation with a physician. Product quality cannot be guaranteed when purchased outside authorized medical institutions.