Noevir Group Discovers that 'Soymilk-Derived High-Purity Isoflavones' from Kyushu-grown 'Fukuyutaka' Soybeans Strengthen Skin Barrier Function

Noevir Group has found that 'Soymilk-Derived High-Purity Isoflavones,' extracted from Kyushu-grown 'Fukuyutaka' soybeans using unique purification technology, strengthen the skin barrier by increasing the levels of Cystatin A (CSTA), a key protein for the skin barrier. This effect contributes to improved skin hydration, not only at the cellular level but also in human skin. Using the latest proteome analysis, the researchers identified the link between Cystatin A and skin barrier function, further advancing the study of soybean functionality. This discovery suggests that this ingredient can strengthen the skin's barrier, unleashing the skin's inherent power and leading to 'strong, well-moisturized skin' that is less susceptible to external stimuli. These research findings will be presented at the 26th Annual Meeting of the Japanese Society of Anti-Aging Medicine, to be held from June 26 to 28, 2026.

[Research Background]
The skin barrier plays a critical role in retaining moisture and protecting the skin from external stimuli. Its deterioration can lead to various skin issues like dryness and inflammation. Recently, the rapid advancement of proteome analysis technology has enabled comprehensive analysis of stratum corneum proteins, opening new avenues for identifying components that contribute to barrier improvement.

[Research Results]
1. Cystatin A is deeply involved in skin barrier function
Through proteome analysis investigating the correlation between Cystatin A and transepidermal water loss (TEWL) in the cheeks of 43 adults, it was confirmed that higher levels of Cystatin A significantly correlate with lower TEWL, indicating a stronger skin barrier.

2. Discovery of the effect of 'Soymilk-Derived High-Purity Isoflavones' on increasing Cystatin A
In tests using human epidermal keratinocytes, it was confirmed that 'Soymilk-Derived High-Purity Isoflavones,' extracted using the company's proprietary technology, increase the expression of Cystatin A.

3. Confirmed strengthening of skin barrier function with 'Soymilk-Derived High-Purity Isoflavones' in human skin
A one-month continuous use trial confirmed a reduction in TEWL, an indicator of skin barrier function, in the group that used a formulation containing this ingredient.