Nihon Trim Co-Sponsors Luncheon Seminar at the 71st Annual Meeting of the Japanese Society for Dialysis Therapy

Nihon Trim Co., Ltd. (Headquarters: Osaka City; President and CEO: Norio Tahara; hereinafter “Nihon Trim”), the market leader in home water purifier sales by revenue※1, will co-host a luncheon seminar titled 'Electrolyzed Water Dialysis for Improving QOL in Dialysis Patients' on Sunday, June 21, 2026, during the 71st Annual Meeting of the Japanese Society for Dialysis Therapy (Venue: Kobe International Conference Center, Kobe, Hyogo Prefecture), to be held from Friday, June 19 to Sunday, June 21, 2026.

※1 2023 Domestic Market for Home Water Purifiers – Total Series Product Value Based on Manufacturer Shipment Revenue for Main Units

Survey by Yano Economic Research Institute, Ltd., as of June 2025 (Survey results are estimates based on qualitative research and analysis methods.)

Founded in 1968 as an informal academic group called the Artificial Dialysis Research Society, the Japanese Society for Dialysis Therapy aims to advance academic research on blood purification therapies, particularly dialysis treatment. The annual academic meeting brings together numerous professionals, researchers, and industry representatives involved in dialysis care to exchange opinions and discussions. It also serves as a platform to gather the latest information and knowledge on dialysis medicine. This year’s meeting is themed 'EMPOWER THE PEOPLE. Energizing Renal Replacement Therapy.' Since 2005, our company has participated in this society to promote awareness of Electrolyzed Water Dialysis® as a novel dialysis therapy.

Overview of the Nihon Trim Luncheon Seminar

Date and Time: Sunday, June 21, 2026, 12:30–13:30

Venue: Room 3A, 3rd Floor, Building 2, Kobe International Exhibition Hall (Venue 21)

Title: Electrolyzed Water Dialysis for Improving QOL in Dialysis Patients

【Presentation 1】Introduction of the Electrolyzed Water Dialysis System at Our Hospital and Future Expectations

Moderator: Dr. Shuzo Kobayashi, President, Shonan Kamakura General Hospital, Tokushukai Medical Corporation

Speaker: Dr. Shinichiro Nishio, Vice President, Niiwakai Clinic

【Presentation 2】Dialysis Fatigue and Energy Metabolism: Emerging Fundamental Pathologies

Moderator: Dr. Takahiro Tatsuzaki, Department of Nephrology, Tokyo Central Hospital, Association for Aid and Relief, Japan; Director, Fujimizawa Fujimizawa Clinic, Izumi Kai Medical Corporation

Speaker: Dr. Masakiyo Nakayama, Visiting Researcher, Research Management Division, St. Luke’s International University

Additionally, during the conference period from Friday, June 19 to Sunday, June 21, we will operate an exhibition booth introducing 'Electrolyzed Water Dialysis®'.

Last year’s luncheon seminar　　　　　　　Last year’s exhibition booth

What is Electrolyzed Water Dialysis®?

Hemodialysis, used to treat patients with renal failure, is a water-intensive therapy, consuming approximately 120 liters of water per session. In 1997, through joint research with Kyushu University, our company was the first in the world to discover the antioxidant properties of 'electrolyzed reduced water (Sui-sui)' and conceived the idea of applying it to hemodialysis, initiating the development of 'Electrolyzed Water Dialysis®'. Through collaborative industry-academia research with institutions such as Tohoku University starting in 2005, we identified that hydrogen molecules (H2) act as key factors in Electrolyzed Water Dialysis®, exerting antioxidant effects and enhancing biocompatibility. Subsequently, while collecting clinical data, we developed dialysis systems (patented domestically and internationally). In 2011, we launched the 'Electrolyzed Water Dialysis® System', and in 2020, we released the standardized 'Electrolyzed Water Dialysis Water Production Unit'. As of the end of May 2026, the system has been introduced in 37 facilities in Japan, with a total of 1,127 beds offering Electrolyzed Water Dialysis®.

Electrolyzed Water Dialysis System Flowchart

Representative Published Papers on Electrolyzed Water Dialysis®

(1) Renal Replacement Therapy (2016) 223 (Review Article)

'Molecular hydrogen as an antioxidant therapy: Clinical applications and perspectives in hemodialysis'

URL: https://www.nihon-trim.co.jp/news/1554/

(2) Scientific Reports (2018) Jan 10;8(1):254 (5-year prospective observational study)

'Electrolyzed water dialysis reduces mortality and cardiovascular complication risks in hemodialysis patients by 41%'

URL: https://www.nihon-trim.co.jp/research/1048/

(3) Renal Replacement Therapy (2021) 7:37

'Electrolyzed water dialysis reduces oxidative stress, a cause of dialysis-related fatigue'

URL: https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-021-00353-9

(4) Renal Replacement Therapy (2021) 7:58

'Severe dialysis-related fatigue nearly disappears with electrolyzed water dialysis'

URL: https://www.nihon-trim.co.jp/research/3829/

Figure: Trends in dialysis fatigue the day after dialysis

* The cutoff value for presence or absence of substantial fatigue was determined from the ROC curve of the original questionnaire, with a VAS score of 4 or higher indicating substantial fatigue.

*: P<0.05, **: P<0.01 (Significant difference compared to before)

(5) Renal Replacement Therapy (2022) 8:32

'Confirmation of severe fatigue reduction effect by electrolyzed water dialysis and discovery of factors enhancing this effect'

URL: https://www.nihon-trim.co.jp/research/4257/

About Nihon Trim

Founded in 1982 by current Chairman Shinsho Morisawa, Nihon Trim Co., Ltd. primarily engages in the manufacturing and sales of medical devices, specifically electrolyzed hydrogen water purifiers. Pioneering the concept of functional water, the company has pursued the benefits and functionality of hydrogen-rich water® through over 30 years of collaborative industry-government-academia research.

Today, applications of electrolyzed hydrogen water extend beyond drinking, being utilized in next-generation dialysis therapies and crop cultivation, among other fields. Additionally, through its group company, Stem Cell Research Institute, Inc. (Tokyo Stock Exchange Growth Market: 7096), Japan's largest private cord blood bank, the Nihon Trim Group aims to become a global medical company.

Company Name / Nihon Trim Co., Ltd. (Tokyo Stock Exchange Prime Market: 6788)

□ Date of Establishment: June 12, 1982 (Showa 57)

□ President and CEO: Norio Tahara

□ Capital: 992,597,306 JPY

□ Number of Employees: 777 (as of March 31, 2026, including affiliated companies)

□ Corporate Website: https://www.nihon-trim.co.jp/