Discovery of the Pioneer Transcription Factors 'FOXF1/2' Responsible for Senescent Cells Causing Chronic Inflammation - Controlling Age-Related Chronic Inflammation -

Kumamoto University, formed in 1949 from institutions including the former Fifth Higher School and Kumamoto Medical University with traditions dating back to the Meiji era, serves as a core comprehensive university in Kyushu. It is dedicated to high-level education, research, and social contribution while maintaining close ties with local and international communities. As an educational and research hub open to the region and the world, it strives to achieve SDGs through various frameworks across national, regional, and disciplinary boundaries.

We have discovered the pioneer transcription factors 'FOXF1/2' that play a crucial role in the mechanism by which senescent cells induce chronic inflammation. This finding represents a significant breakthrough in understanding and controlling age-related chronic inflammation. Chronic inflammation is a major contributor to many age-related diseases, including cardiovascular diseases, neurodegenerative disorders, and cancer. By identifying FOXF1/2 as a key regulator, we open up potential new therapeutic strategies to combat these conditions. Further research will focus on developing interventions that target FOXF1/2 to modulate inflammatory responses and promote healthier aging.