SCIEX ZenoTOF Series Evolves with Platform Expansion via Software, Integrated Processing, and Collaboration

Marlborough, MA — SCIEX, a Danaher company and a global leader in life science analytical technologies, announced a platform evolution across its ZenoTOF series of high-resolution mass spectrometers at ASMS. This update includes new SCIEX OS 5.0 software features, expanded front-end compatibility, and future-oriented software integrations designed to support omics researchers in complex biological studies. These connected research environments reduce workflow complexity and enable deeper, actionable insights from a single, dynamic platform.

SCIEX OS 5.0 introduces new features such as a central metrics tracker, central monitoring, a reporter template creator, AI-powered 'helpme' functionality, and AI-powered calculation columns. Furthermore, specific evolutions for the ZenoTOF series include:

- ZT Scan DIA 3.0: By combining the comprehensiveness of Data-Independent Acquisition (DIA) with narrower Q1 isolation windows, researchers can optimize the balance of selectivity, sensitivity, and throughput based on experimental requirements. This technology enables scalable proteomics and robust metabolomics analysis, reducing workflow complexity and expanding the application areas supported by a single platform.

- Enhanced sensitivity mode: Demonstrates significant performance improvements in nano-flow-based trace protein sample measurements on the ZenoTOF 8600 system, with approximately 10–40% improvement in both protein identification and quantification.

Expanded front-end compatibility for the ZenoTOF series:

- Integration of Echo® MS+ and ZenoTOF 8600: This integration provides a high-resolution mass spectrometry platform with industry-leading throughput, capable of measuring up to one sample per second. It serves as a foundational screening technology that delivers high sensitivity in high-throughput screening, accelerating initial discovery, simplifying workflows, and reducing consumable costs.

- HDX-MS by Trajan Scientific and Medical: Provides advanced automated sample preparation and comprehensive data processing, enabling deeper insights into protein structure and binding. Combined with the EAD of the ZenoTOF series, these technologies realize an integrated end-to-end solution for HDX-MS with high sensitivity and amino acid residue-level resolution without deuterium scrambling.

- New ion source enhancements: Enables seamless compatibility between Evosep, IonOpticks, and the ZenoTOF series. This allows researchers to maximize the Whisper Zoom method and accelerate next-generation proteomics analysis on an integrated SCIEX platform that combines high sensitivity, robustness, and throughput. Additionally, a partnership between SCIEX and IonOpticks plans to expand access to advanced liquid chromatography solutions, including Aurora XS columns.

Collaborations with major software platforms allow researchers to leverage existing workflows and proprietary solutions:

- PEAKS software: As a key integration, advanced AI-based proteomics analysis by BSI is now available across the ZenoTOF series. This allows researchers to achieve biomarker identification, quantification, and validation on a single solution, bridging the gap between 'discovery' and 'targeted quantification.' This reduces complexity in translational research and contributes to improved reproducibility.

- MS-DIAL: Acts as a pioneering collaborator in converting ZT Scan DIA 3.0 measurement data into life science insights. Users can utilize this trusted software for metabolomics and lipidomics profiling to discover novel biomarkers.

- Integration with MZIO: SCIEX data is now compatible with mzmine, allowing users to integrate SCIEX data into existing metabolomics and small molecule analysis pipelines, enabling scalable data processing, advanced feature extraction, and downstream analysis across diverse MS workflows.

Jose Castro-Perez, Vice President of Product Management at SCIEX, stated: 'What we are delivering is not just incremental performance improvement. It is a leap forward that transforms the very way researchers conduct studies across the entire omics landscape. This is just the beginning. Our commitment is simple: we will continue to provide value to our customers in every workflow through continuous innovation on this platform.'