Head Spring Group's Manufacturing Base "mL BASE" Acquires International Standard "ISO 22716" Certification for Cosmetics GMP

Medlf Inc. (Location: Fukui City, Fukui; CEO: Ryota Izumi), the group manufacturing base of Head Spring Holdings Co., Ltd. (HQ: Shinjuku-ku, Tokyo; CEO: Narito Izumi), which leads product sales support and cosmetics development for aesthetic medicine and private practice clinics, has acquired the international standard "ISO 22716 (Cosmetics GMP)" certification for its in-house cosmetics manufacturing lab, "mL BASE." This certification establishes a world-class manufacturing and quality control system at our group's manufacturing base, mL BASE. In our system that handles everything from planning to manufacturing within the group, the reliability of quality assurance in the manufacturing process has been further enhanced. ■ Strength as a Vertically Integrated Group: Pursuing "Transparency" from Planning to Manufacturing The Head Spring Group operates a "vertically integrated" business model where three companies work in close collaboration: "DMS," which handles clinic DX and patient acquisition; "Head Spring," which supports product sales and OEM contracts; and "Medlf," which has a manufacturing base in Fukui City, Fukui. As the doctor's cosmetics market matures, doctors are increasingly demanding not only the effectiveness of ingredients but also transparency regarding "how safely a product is manufactured." The acquisition of ISO 22716 by "mL BASE" aims to eliminate the opacity of the manufacturing process through this group-wide integrated system and provide reliable quality to doctors. Certificate & Certification Mark ■ Medlf's "mL BASE" Realizes a New Standard for Aesthetic Medicine OEM 1. 【Small Lots】Agility and Risk Reduction Starting from 200 Units Typically, world-standard GMP-certified factories focus on large-lot production for efficiency, but Medlf supports ultra-small lot manufacturing from "200 units." This minimizes inventory risk when giving form to a clinic's unique vision while applying world-standard management processes. 2. 【Quality】Strict Management System with Almost No Corrective Actions In the recent audit, Medlf's "mL BASE" achieved certification at an extremely high level, with only one corrective action required. From raw material receiving to blending, filling, and shipping, all processes adhere to strict hygiene and record-keeping management based on international standards. 3. 【Aesthetic Medicine】Realizing the Doctor's "Prescription Intent" By having expertise in clinic support within the group, we are well-versed in the high-concentration formulas and delicate ingredient combinations specific to doctor's cosmetics. We sublimate the doctor's passion into a product with world-class safety and peace of mind. ■ Representative Comments Narito Izumi, CEO, Head Spring Holdings Co., Ltd. "As a trusted partner to doctors, our mission is to provide the highest standard of products and services. This ISO acquisition has further strengthened the trust foundation of our entire group." Ryota Izumi, CEO, Medlf Inc. "The role of mL BASE is to give 'form' to a doctor's passion without any compromise. We will enforce uncompromising quality control even for small lots and contribute to the further development of Japan's aesthetic medicine industry." 【About Head Spring Group】 Centered on product sales support for aesthetic medicine clinics, we provide total support from product planning, manufacturing, and pharmaceutical affairs law compliance to DX support. With our group manufacturing base "mL BASE (Medlf)" at its core, we introduce evidence-based, high-performance skincare to the world. Holdings: Head Spring Holdings Co., Ltd. (Shinjuku-ku, Tokyo) URL: https://head-spring-hd.co.jp/ Manufacturing Base: Medlf Inc. mL BASE (2-2-13 Minamiyotsui, Fukui City, Fukui) URL: https://medlf.co.jp/