【Medical Corporation Katsujukai x Kobe University】 "Key to Effectiveness" of Knee Regenerative Medicine Identified｜Joint Research Paper Published in International Academic Journal

Medical Corporation Katsujukai Knee Joint Clinic (Location: Shinjuku-ku, Tokyo / Director: Masaki Otsuji) is pleased to announce that the results of their joint research on regenerative medicine with Kobe University have been published in the international academic journal "Cell Transplantation." This groundbreaking study provides scientific evidence for "individual differences in the effectiveness of regenerative medicine," which has largely been discussed based on anecdotal experience until now.

This research was conducted as a joint study by knee osteoarthritis clinics nationwide and a research group at Kobe University, led by Dr. Naoki Nakano (Specially Appointed Assistant Professor of Orthopedic Surgery, Kobe University, and affiliated with Knee Joint Clinic Kobe).

The study scientifically verified the efficacy and safety of adipose-derived stem cell (ASC) therapy for knee osteoarthritis.

Paper URL: https://journals.sagepub.com/doi/10.1177/09636897251414212

"Cell Transplantation" is an international academic journal specializing in regenerative medicine and cell therapy, featuring the latest research findings from researchers worldwide. Only studies adopted after rigorous peer review are published, making it a highly respected international journal.

■ Overview of the Research

In this study, the effectiveness of adipose-derived stem cell (ASC) therapy at Knee Joint Clinic was verified for patients with "knee osteoarthritis" accompanied by knee pain and deformation.

Specifically, the study meticulously analyzed how treatment effectiveness and post-treatment progress differ depending on the stage of symptom progression (severity) classified by X-ray imaging.

■ Main Results

・Higher treatment efficacy was confirmed in patients with moderate cartilage wear (progressive stage).

・Significant treatment efficacy was also observed in patients with severe cartilage wear (end-stage).

・The pain reduction effect showed a tendency to gradually increase for approximately 6 months after treatment.

・No severe side effects were observed, and safety was confirmed.

■ Comment from Dr. Naoki Nakano (Specially Appointed Assistant Professor, Kobe University, Part-time Doctor at Knee Joint Clinic)

Currently, while regenerative medicine for knee osteoarthritis is diversifying, its efficacy and validity vary, making the importance of treatment selection based on scientific evidence even higher. This study is significant in that it verified the efficacy and safety of adipose-derived stem cell therapy using clinical data from Knee Joint Clinic, which has a leading track record of treatments in Japan. As it is based on a sufficient number of cases, it is expected to contribute to future treatment selection as a practical clinical insight.

■ Academic Initiatives of Knee Joint Clinic

While regenerative medicine holds great potential, it is also a field where the accumulation of scientific evidence— "which treatment is effective for which patient, and to what extent"—is crucial.

Knee Joint Clinic will continue to collaborate closely with research institutions, including universities, to continuously conduct scientific verification of clinical data, and actively disseminate findings domestically and internationally through academic presentations and paper publications, thereby contributing to the establishment of evidence and improvement of medical quality in the field of regenerative medicine.

【Company Information】

Company Name: Medical Corporation Katsujukai Knee Joint Clinic

Company Location: 9F Hojo Building, 1-4-11 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023

Director: Masaki Otsuji

Representative Phone: 03-6705-8994

Website URL: https://www.knee-joint.net/

Business Activities: Regenerative medicine clinic specializing in knee pain (private practice)

Established: March 2015

＜Media Contact＞

For inquiries, please contact us by email (pr@knee-joint.net).

Medical Corporation Katsujukai Public Relations: Kagura, Toriha

TEL: 03-6419-7374 (Head Office), Mobile: 080-7275-0993 (Public Relations Window)