Potential for Lifestyle-Related Disease Prevention Through Behavioral Change Using Zene360 Genome Analysis Results Presented at the 41st Annual Meeting of the Japanese Society for Clinical Nutrition and Metabolism
At the 41st Annual Meeting of the Japanese Society for Clinical Nutrition and Metabolism, a study by Dr. Yoshitaka Hashimoto and colleagues at Matsushita Memorial Hospital demonstrated that health counseling incorporating Zene's 'Zene360' genome analysis results significantly increased daily step counts and reduced lipid intake. This exploratory randomized controlled trial suggests that utilizing personalized genetic information can effectively encourage positive behavioral changes for lifestyle-related disease prevention.
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Zene Inc. (hereinafter 'Zene') is pleased to announce that findings from a study utilizing Zene's genome analysis service 'Zene360' were reported at the 41st Annual Meeting of the Japanese Society for Clinical Nutrition and Metabolism. The research, titled 'The Impact of Genome Analysis Results on Behavioral Change for Lifestyle-Related Disease Prevention: An Exploratory Randomized Controlled Trial,' was presented by Dr. Yoshitaka Hashimoto and his team from the Department of Diabetes and Endocrinology at Matsushita Memorial Hospital.
This study was an exploratory randomized controlled trial that examined how providing individuals with information on their genetic predispositions related to lifestyle-related diseases, followed by health counseling, influences daily behavioral change. The study targeted 224 employees of the Panasonic Health Insurance Association Matsushita Memorial Hospital, who were assigned to either a results-disclosure group (111 people) or a non-disclosure group (113 people). The primary endpoint was changes in step counts, while secondary endpoints included changes in body composition and dietary intake.
In the analysis of step count data, the results-disclosure group saw their daily steps increase from 6,567 to 7,222, a change of +654 steps/day. In contrast, the non-disclosure group decreased from 7,487 to 7,209 steps, a change of -278 steps/day. The difference in change between the two groups was 932 steps/day, demonstrating a statistically significant difference. Furthermore, in a linear mixed model adjusted for age, gender, BMI, etc., the effect of the disclosure intervention was reported as 932.07 steps/day.
Additionally, regarding dietary intake analysis, the results-disclosure group showed a significant reduction in lipid intake. In the linear mixed model, the impact of the disclosure intervention on lipid intake was -4.43g/day, suggesting positive changes in dietary habits in addition to physical activity.
In conclusion, this study suggests that health counseling utilizing results of genetic predispositions may contribute to behavioral change for lifestyle-related disease prevention, particularly through increased physical activity and reduced lipid intake. While the paper notes that this approach could be a new method for preventing lifestyle-related diseases, it also indicates that the validation period was relatively short at three months and that the long-term disease prevention effect itself remains a topic for future verification.
'Zene360,' provided by Zene, was used in this study as a platform to support individual behavioral change by presenting not only genetic risk information related to type 2 diabetes, heart disease, and cerebrovascular disease, but also genomic information related to diet, exercise, and alcohol consumption. This presentation demonstrates the potential to connect genomic information directly to lifestyle improvement behaviors, rather than just treating it as a visualization tool.
Zene will continue to promote the social implementation of preventive medicine and behavioral change support utilizing genome analysis through collaborations with medical institutions, research organizations, and health insurance associations.
Presentation Overview
Conference: 41st Annual Meeting of the Japanese Society for Clinical Nutrition and Metabolism
Title: The Impact of Genome Analysis Results on Behavioral Change for Lifestyle-Related Disease Prevention: An Exploratory Randomized Controlled Trial
Presenter: Dr. Yoshitaka Hashimoto and others
Research Content: An exploratory randomized controlled trial examining the effects of health counseling that includes the presentation of genome analysis results on step counts, dietary habits, and body composition.
This study was an exploratory randomized controlled trial that examined how providing individuals with information on their genetic predispositions related to lifestyle-related diseases, followed by health counseling, influences daily behavioral change. The study targeted 224 employees of the Panasonic Health Insurance Association Matsushita Memorial Hospital, who were assigned to either a results-disclosure group (111 people) or a non-disclosure group (113 people). The primary endpoint was changes in step counts, while secondary endpoints included changes in body composition and dietary intake.
In the analysis of step count data, the results-disclosure group saw their daily steps increase from 6,567 to 7,222, a change of +654 steps/day. In contrast, the non-disclosure group decreased from 7,487 to 7,209 steps, a change of -278 steps/day. The difference in change between the two groups was 932 steps/day, demonstrating a statistically significant difference. Furthermore, in a linear mixed model adjusted for age, gender, BMI, etc., the effect of the disclosure intervention was reported as 932.07 steps/day.
Additionally, regarding dietary intake analysis, the results-disclosure group showed a significant reduction in lipid intake. In the linear mixed model, the impact of the disclosure intervention on lipid intake was -4.43g/day, suggesting positive changes in dietary habits in addition to physical activity.
In conclusion, this study suggests that health counseling utilizing results of genetic predispositions may contribute to behavioral change for lifestyle-related disease prevention, particularly through increased physical activity and reduced lipid intake. While the paper notes that this approach could be a new method for preventing lifestyle-related diseases, it also indicates that the validation period was relatively short at three months and that the long-term disease prevention effect itself remains a topic for future verification.
'Zene360,' provided by Zene, was used in this study as a platform to support individual behavioral change by presenting not only genetic risk information related to type 2 diabetes, heart disease, and cerebrovascular disease, but also genomic information related to diet, exercise, and alcohol consumption. This presentation demonstrates the potential to connect genomic information directly to lifestyle improvement behaviors, rather than just treating it as a visualization tool.
Zene will continue to promote the social implementation of preventive medicine and behavioral change support utilizing genome analysis through collaborations with medical institutions, research organizations, and health insurance associations.
Presentation Overview
Conference: 41st Annual Meeting of the Japanese Society for Clinical Nutrition and Metabolism
Title: The Impact of Genome Analysis Results on Behavioral Change for Lifestyle-Related Disease Prevention: An Exploratory Randomized Controlled Trial
Presenter: Dr. Yoshitaka Hashimoto and others
Research Content: An exploratory randomized controlled trial examining the effects of health counseling that includes the presentation of genome analysis results on step counts, dietary habits, and body composition.