Regenosome jointly files patent for bicelle formulation that stably delivers retinol

Regenosome Co., Ltd. (Headquarters: Minato-ku, Tokyo; President: Zentaro Sakuma), a venture company in the longevity field and a group company of Space Seed Holdings Inc. (Headquarters: Minato-ku, Tokyo; President: Kengo Suzuki), has jointly filed a patent for a bicelle formulation that stably encapsulates retinoids (a general term for vitamin A and its derivatives, with retinol being one type of retinoid). This patent is the result of joint research with Specially Appointed Associate Professor Noriyuki Uchida of the Department of Applied Chemistry at Tokyo University of Agriculture and Technology (Patent Application No. 2026-084416, Filing Date: May 19, 2026). Regenosome aims to implement research results into society and will use this patent as a starting point to advance product development and practical application in the healthcare field.

Background: The usefulness of retinol and its handling difficulties

Retinol (vitamin A) is a well-known beneficial ingredient in the healthcare field. However, it is generally known that its susceptibility to factors like air and light makes it difficult to maintain stability, and its usability also requires careful consideration, posing challenges for its application. Technologies that can deliver such ingredients stably and with consideration for skin gentleness have been in demand.

About Bicelle Formulations

"Bicelles" are drawing attention as one type of nano-sized formulation carrier for delivering beneficial ingredients. By encapsulating beneficial ingredients within the carrier, it is expected that the ingredients can be delivered while maintaining their stability.

We have been advancing research on bicelle formulations that stably encapsulate retinoids, and the results of this research have been compiled into the current patent application.

Application Overview

Item

Details

Application Number

Patent Application No. 2026-084416

Filing Date

May 19, 2026

Applicants

Regenosome Co., Ltd. / Space Seed Holdings Inc. / Tokyo University of Agriculture and Technology

Content

Invention related to a bicelle formulation that stably encapsulates retinoids

Future Development

Starting with this patent, we will proceed with considerations for product development and practical application in the healthcare field. We aim to connect technologies that deliver beneficial ingredients, including retinol, with consideration for stability, to forms that reach consumers.

*Specific products, timelines, and specifications are undecided. We will announce again once they are finalized.

About Regenosome Co., Ltd.

Regenosome aims to provide new solutions for anti-aging and regenerative medicine utilizing nanoparticles. We have established our headquarters and research facility, "Takanawa Longevity Lab," at TAKANAWA GATEWAY CITY's "LiSH (Link Scholars' Hub)" and are accelerating research and development for the expansion of our healthcare business under our own brand "SAISEI LAB" and for future entry into the medical field. In the future, we aim to contribute to the extension of healthy life expectancy and humanity's expansion into space.

https://regenesome.com/

About Space Seed Holdings Inc.

Space Seed Holdings is a space-themed deep tech venture builder that engages in investment, research, and business creation with the mission of "making science fiction a non-fiction." Centered around programs such as the "Fermentation and Longevity Fund" which supports the social implementation of fermentation and longevity technologies, we are working to create businesses that solve societal issues. By 2040, we aim to have the technologies necessary for humanity to reside in space, together with various stakeholders.

https://ss-hd.co.jp/