Roche Infectious Disease Award 2025 Winners Announced: Honoring 13 Experts Dedicated to the Front Lines of Infectious Disease Research and Control

Roche Diagnostics K.K. (Headquarters: Minato-ku, Tokyo / President and CEO: Kei Maeda, hereinafter Roche) is pleased to announce the winners of the "Roche Infectious Disease Award 2025," which honors outstanding research and activities in the field of infectious diseases. This award was established by Roche in 2022 to honor professionals who are at the forefront of infectious disease research and countermeasures in a modern society that coexists with infectious diseases, and to contribute to the healthy lives of people. For fiscal year 2025, the fourth time the award has been given, 29 excellent applications were received from domestic universities, hospitals, research institutes, etc. After strict screening, the winners were determined as follows. Roche provides a wide variety of infectious disease-related tests that people need from the perspectives of prevention, diagnosis, and disease management. Through this award, which honors contributions to medicine in the infectious disease field, we will support the further development of research and countermeasures, and aim to realize a sustainable society. Roche Infectious Disease Award 2025 Winners "Excellence in Science Category": 9 winners Grand Prize (Grant of 1,000,000 yen) Nozomi Takahashi, Department of Emergency and Critical Care Medicine, Chiba University Hospital Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock Her original perspective of applying the approaches of "lipid profiles" and "genetic polymorphisms" to sepsis, a fatal acute pathology causing organ failure triggered by infection, was highly evaluated. Although an extremely challenging endeavor, she has verified the hypothesis of production and clearance in metabolic pathways over a long period, and it was praised as a highly complete study. This achievement holds the potential to directly lead to the discovery of new therapeutic targets and the elucidation of dynamics, and great expectations are placed on its development into future prognostic analysis and clinical applications. It was highly evaluated as an extremely excellent basic research that brings a tremendous contribution to the progress of infectious disease medicine, deeply aligning with the philosophy of this award, which advocates "contribution to infectious disease medicine." Excellence Award (Grant of 500,000 yen) Yoshinori Uemino, Department of Laboratory Medicine, Keio University School of Medicine Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity Atsushi Tsuchiya, Department of Gastroenterology, Institute of Science Tokyo Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model Naokatsu Ando, AIDS Clinical Center, National Center for Global Health and Medicine Prolonged sitafloxacin and doxycycline combination regimen for treating infections by highly resistant Mycoplasma genitalium Winning Entries (Grant of 300,000 yen) Kazuhiro Murai, Department of Gastroenterology, Graduate School of Medicine, Osaka University Atsushi Inoue, Department of Gastroenterology, Tohoku University Hospital Masatsugu Ohara, Department of Gastroenterology, Hokkaido University Hospital Hiroki Kitagawa, Department of Infectious Diseases, Hiroshima University Hospital (Remaining names truncated in source data)