Patent Registered for Exfoliation Improving Agents 'Otomeyuri' and 'Tarragon'

Naris Cosmetics Co., Ltd. (Headquarters: Fukushima-ku, Osaka; President: Hiroyoshi Muraoka), as a result of its continuous stratum corneum research for about 90 years, has discovered two plant ingredients (Otomeyuri and Tarragon) that promote exfoliation and has registered a patent. The details are summarized below. By incorporating these ingredients into wipe-off lotions, we aim to provide a stratum corneum care experience that delivers higher efficacy and brings out the inherent beauty of each individual. *Our company refers to the outermost layer of the skin itself as the 'stratum corneum' and unnecessary aging keratin as 'keratin'.

Research Background

Since the launch of 'Naris Conc', a wipe-off lotion aimed at nourishing the skin by removing aging keratin in 1937, our company has continuously conducted stratum corneum research. It is known that proteins undergo various changes such as glycation, carbonylation, and nitration from birth until they peel off as aging keratin. We investigated how these protein changes affect the final desquamation and presented our findings at the IFSCC Congress, an international conference for cosmetic chemists, held in 2020.

Presentation Title: Protein modification leading to serious skin desquamation loss

Previous Research and Patent Content

Stratum corneum desquamation involves factors that adhere corneocytes and enzymes that break down these adhesion factors. Our research, which examined the relationship between stratum corneum thickness and related components, confirmed that when the corneocyte adhesion factor DSG1 undergoes glycation, carbonylation, and nitration, its decomposition by degrading enzymes is suppressed. As a result, we clarified that normal desquamation may not occur, potentially leading to thickening of the stratum corneum. We discovered 'Otomeyuri', which has small pink petals, and 'Tarragon', a herb also known as a spice used in cooking, as ingredients that prevent or resolve this difficulty in decomposing adhesion factors, and have now registered the patent.