Morinaga study suggests piceatannol-containing food may improve crow’s feet wrinkles after eight weeks

Morinaga & Co. is advancing research into the functionality of piceatannol, a type of polyphenol. The company announced that a human study in healthy adults found that continuous intake of food containing piceatannol for eight weeks may improve wrinkles at the corners of the eyes. The study enrolled healthy Japanese women aged 30 to 59 who were concerned about dry skin. Participants consumed either a beverage containing 10 mg of piceatannol or a placebo beverage without piceatannol for eight consecutive weeks. Researchers measured crow’s feet wrinkles and stratum corneum moisture levels in the cheeks before and after intake. The piceatannol beverage group showed significant improvement in crow’s feet wrinkles compared with the placebo group, and cheek stratum corneum moisture levels also improved significantly. Morinaga said the findings suggest that continuous piceatannol intake may help maintain stratum corneum moisture and improve wrinkles around the eyes. The study was published on April 28, 2026, in the peer-reviewed international journal Frontiers in Nutrition under the title “Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.” The company noted that the study was conducted in healthy adults and may not apply to everyone. The findings are not intended for the treatment or prevention of disease. Morinaga is currently using piceatannol as a core focus in its challenge for XPRIZE Healthspan, a global competition with a $100 million prize that aims to achieve at least 10 years of rejuvenation by 2030.