Discovery: Fucoxanthin from Marine Microalgae Inhibits SASP, a Key Accelerator of Skin Aging

A research group led by Professor Masaki Yoshida of the Department of Food and Cosmetic Science, Faculty of Applied Bioscience, Tokyo University of Pharmacy and Life Sciences (Hachioji, Tokyo; President: Yutaka Kagawa), in collaboration with circuRE act Co., Ltd. (headquartered in Chiyoda, Tokyo; CEO: Shoko Shiohara), has discovered that 'fucoxanthin' contained in the marine microalga Fistulifera solaris inhibits SASP (Senescence-Associated Secretory Phenotype).

This research result will be presented at the '51st Annual Meeting of the Japanese Society of Cosmetics,' to be held on June 25–26, 2026.

【Research Background】
SASP refers to the phenomenon in which aged cells secrete inflammatory substances such as cytokines. This leads to accelerated aging of surrounding cells, chronic inflammation, and destruction of skin structure, thereby promoting aging symptoms such as wrinkles and sagging. These effects are exacerbated by ultraviolet radiation (UVB), making SASP a major contributor to photoaging. In this study, the research team focused on 'fucoxanthin,' a component found in the extract of the microalga Fistulifera solaris, and evaluated its impact on SASP factors in epidermal cells.

【Research Content and Results】
Using in vitro assays with epidermal cells, the research team measured the expression levels of various cytokines after adding fucoxanthin, both in UVB-irradiated and non-irradiated groups, using PCR analysis. The results showed that UVB irradiation increased inflammatory substances such as IL-6 and MCP-1, as well as MMP-3, an enzyme that degrades skin collagen. However, the addition of fucoxanthin significantly suppressed these increases. Notably, the suppression of IL-6 and MCP-1 was particularly pronounced. In contrast, the effect on MMP-1 was limited. Additionally, an increasing trend was observed in involucrin, a protein involved in skin barrier formation.

Dried biomass and extracted essence of the marine microalga Fistulifera solaris

【Academic Significance and Future Outlook】
The study demonstrates that fucoxanthin suppresses the expression of SASP-related factors that trigger inflammation and skin structural degradation. This suggests that fucoxanthin may help interrupt the chain reaction of skin aging and contribute to maintaining healthy skin, including improved barrier function. Fucoxanthin may be effective against both intrinsic aging and photoaging, making it a promising candidate for novel anti-aging ingredients.

(Note 1) Fistulifera solaris: Characterized by exceptionally high fucoxanthin content compared to macroalgae such as kelp and wakame (950–1000 mg per 100 g on a dry weight basis). Historically considered a rare material difficult to mass-produce, the company plans to establish a domestic, end-to-end production system for cultivation, extraction, and purification.

Comparison of fucoxanthin content in various seaweeds

【Conference Presentation】
Conference: 51st Annual Meeting of the Japanese Society of Cosmetics
URL: https://www.jcss.jp/event/51tab-3.html
Presentation Date and Time: Thursday, June 25, 2026, 12:20–13:20, Poster Session ①
Venue: Asahi Hall, Yurakucho (2-5-1 Yurakucho, Chiyoda-ku, Tokyo) / Presentation Location: 11th Floor Exhibition Hall P03
Presentation Title: Inhibition of SASP in Epidermal Cells by Fucoxanthin
※ At the exhibition booth (Booth No. 22, 11th floor), explanations and sample distribution of Solaris extract will be provided.

■ Skin Physiology Research Laboratory (Professor Masaki Yoshida), Faculty of Applied Bioscience, Tokyo University of Pharmacy and Life Sciences
Conducts fundamental research on skin for the development of effective cosmetic ingredients. The primary goal is to establish methods for improving hyperpigmentation, which involves studying not only pigment cells but also epidermal differentiation and proliferation systems.
[Main Research Themes]
1. Regulatory mechanisms of melanocyte migration and melanin synthesis
2. Establishing skin diagnostic methods using vellus hair
3. Regulatory mechanisms of epidermal differentiation and proliferation
4. Clearing analysis of skin in contact dermatitis model mice and dry-sensitive skin model mice
[Research Laboratory Website]
https://masaki-yoshida-lab.bs.teu.ac.jp

■ Overview of circuRE act Co., Ltd.
Develops and sells domestically produced ingredients derived from marine microalgae, a gift from the ocean. The company also plans and sells consumer goods utilizing these ingredients, aiming to reduce environmental impact through sustainable ingredient development.

circuRE act Co., Ltd.
Head Office: 3-28-5 Kanda-Ogawamachi, Chiyoda-ku, Tokyo, axle Ochanomizu
CEO: Shoko Miyasaka (Shiohara)
Founded: March 13, 2023
Website: https://circureact.com/
Official SNS (Instagram): https://www.instagram.com/team530_japan/