Himuka AM Pharma, a Peptide Drug Developer, Concludes Licensing Agreement

Himuka AM Pharma Co., Ltd. (Headquarters: Miyazaki City, Miyazaki Prefecture) announced that it has concluded a licensing agreement with Pharma Foods Co., Ltd. (Headquarters: Nishikyo-ku, Kyoto City, Kyoto Prefecture) regarding the bioactive peptide "Adrenomedullin" (development code HM101). Based on this licensing agreement, the company grants Pharma Foods exclusive rights concerning the research, development, manufacturing, and sales of new drugs within the following scope: Target compound: Adrenomedullin (development code HM101); Target disease: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL); Target regions: Japan, South Korea, and Taiwan. The company is also advancing the drug discovery development of an improved Adrenomedullin (development code HM201: PEGylated Adrenomedullin) and will continue to strengthen its activities toward the creation of new drugs. Adrenomedullin: Adrenomedullin is a bioactive peptide discovered in 1993 by Kazuo Kitamura (the company's scientific advisor, specially appointed professor at Miyazaki University), Kenji Kangawa (honorary director of the National Cardiovascular Center Research Institute), and others. Adrenomedullin has various effects such as angiogenesis, tissue regeneration, and anti-inflammatory action. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL): This is a hereditary cerebrovascular disease caused by mutations in the NOTCH3 gene, and it is certified as a "designated intractable disease" by the Ministry of Health, Labour and Welfare in Japan. The prevalence in Japan is estimated to be 1.20 to 3.58 people per 100,000 adult population. ■Company Profile Company Name: Himuka AM Pharma Co., Ltd. Business: Research and development of new drug discovery seeds, licensing Established: February 1, 2017 Location: 2-5-36 Takachiho-dori, Miyazaki City, Miyazaki Prefecture 880-0812 Website: https://www.himuka-am.com/ Miyazaki University-originated venture company J-Startup company.