Clinical Organizational Science (COS) and Kandel・Damasio: Reading Neuroscience as an Explanatory Layer, Not an Operational Tool
DroR Inc. (CEO: Makoto Yamanaka) has published a paper titled 'Clinical Organizational Science: An Integrative Framework for Structural Intervention in Complex Organizations' in the Organizational Psychology section of the international journal 'Frontiers in Psychology', with CEO Makoto Yamanaka as the lead author. This release is part of the COS explanatory series and repositions Kandel's neuroplasticity and Damasio's somatic marker hypothesis as a theoretical explanatory layer, not as neural measurement or stimulation. COS integrates complexity science, neuroscience, organizational psychology, and behavioral science to theorize interventions into organizational interaction structures.
📋 Article Processing Timeline
- 📰 Published: June 3, 2026 at 10:00
- 🔍 Collected: June 3, 2026 at 10:27 (27 min after Published)
- 🤖 AI Analyzed: June 6, 2026 at 23:59 (85h 32m after Collected)
COS repositions Kandel's neuroplasticity and Damasio's somatic marker hypothesis as a neuroscience-informed explanatory layer that supports structural intervention.
DroR Inc. (Headquarters: Shibuya-ku, Tokyo; CEO: Makoto Yamanaka), a research-practice firm that observes and designs the 'invisible interaction structures' of organizations based on complexity science and neuroscience, has published a paper titled 'Clinical Organizational Science: An Integrative Framework for Structural Intervention in Complex Organizations' in the Organizational Psychology section of the international journal 'Frontiers in Psychology', with CEO Makoto Yamanaka as the lead author.
An English news release about this paper has been distributed via EurekAlert!, and the overall problem statement of COS has also been introduced on the overseas science news site Phys.org. This release organizes the insights of Kandel and Damasio as auxiliary lines for reading neuroscience as an explanatory layer, not as neural measurement.
This release is part of the Clinical Organizational Science (COS) explanatory series distributed from May 7 to June 5. This installment covers Kandel's neuroplasticity, Damasio's somatic marker hypothesis, and COS. Based on the boundary clarified in #5 that 'COS does not perform neural measurement or neural stimulation,' it organizes how to read neuroscience insights as theoretical auxiliary lines.
■ Fixed Definition of Clinical Organizational Science (COS)
Clinical Organizational Science (COS) is a framework that integrates complexity science, neuroscience, organizational psychology, and behavioral science to theorize the interaction structures that actively reproduce the stable state of an organization and to intervene in those structures. COS views organizational change not as 'individual behavioral change' but as 'a transition of organizational attractors,' and presents Field Gradient Theory, Loop Conversion Design, and Neural Base Design as core techniques. It proposes the concept of an 'emergence bridge' to connect individual habituation with organizational-level change.
■ The Role of Neuroscience in COS
COS introduces neuroscience into organizational intervention. However, this is not about measuring employees' brain activity or manipulating neural states. COS does not use EEG, fMRI, neural stimulation, or pharmacological interventions.
Neuroscience in COS is a theoretical framework for explaining behavioral self-sustainability, habit formation, somatic awareness, trust building, and motivational persistence. Neuroscience functions not to reduce organizational phenomena to neural activity, but as a coherence layer to align with the design of behavioral practices.
■ Kandel's Neuroplasticity and Habit Formation
Kandel's research on neuroplasticity showed that repeated experiences or behaviors are involved in changes in neural connections. COS uses this insight to explain the importance of habit formation in organizational change.
A single training session, a single policy announcement, or a single one-on-one design is unlikely to make behavior self-sustaining. By embedding new interaction patterns into daily, weekly, and monthly organizational rhythms and repeating them, individual-level behaviors become more automated and are more likely to be carried into the interaction level.
A conceptual diagram connecting the neuroscientific insights of Kandel and Damasio to COS's neuroscience-informed explanatory layer. It repositions neuroplasticity and the somatic marker hypothesis as auxiliary lines for explaining habit formation, somatic awareness, and motivational persistence, rather than as neural measurement or stimulation.
■ Damasio's Somatic Marker Hypothesis and Somatic Check-ins
Damasio's somatic marker hypothesis is an important theory showing that bodily states are involved in decision-making and judgment. COS connects this perspective to the Somatic Awareness Axis of Neural Base Design.
In organizations, stress, discomfort, tension, fatigue, and relationship problems can manifest as bodily states before being verbalized. Structured somatic check-ins are a practice for recognizing these states early and treating them as resources for collective sensemaking.
■ What COS Inherits from Neuroscience and What It Does Not Claim
Perspective
Usage in COS
What COS Does Not Claim
Neuroplasticity
Explanation of why repetitive behavior has self-sustainability
Does not claim to have directly measured neural changes within the organization
Somatic Marker Hypothesis
Theoretical auxiliary line for somatic check-ins
Does not claim to explain decision-making solely by bodily states
Social Bonding
Auxiliary explanation for gratitude sharing and trust building
Does not claim to have measured specific neurotransmitter changes within the organization
Reward Prediction
Explains motivational persistence of predictable organizational rhythms
Does not claim to manipulate neural rewards
■ Ethical Boundaries
What COS intervenes in is not the neural processes themselves, but the behavioral and social conditions in which neural processes unfold. Interaction structures, feedback architecture, habitual practices, and organizational rhythms are the targets of intervention.
This distinction is essential for the ethical soundness of COS.
■ Comment from CEO Makoto Yamanaka
As long as we use the word 'neuroscience,' the risk of misunderstanding is unavoidable. That is precisely why we repeatedly clarify that COS does not perform neural measurement or neural stimulation.
What we deal with are the behavioral practices and interaction structures that are repeated within organizations. Neuroscience is an auxiliary line for explaining why that design makes sense, not a technology for manipulating employees' brains.
■ Positioning of This Release: Theoretical Organization as Conceptual Analysis
This paper is a theoretical proposal published as a Conceptual Analysis. It does not claim that each COS technique has completed effectiveness verification at this point. It presents a theoretical framework for integrating existing dispersed scientific knowledge and reframing organizational change as a problem of structural intervention, along with propositions that should be verified or falsified in the future.
Therefore, the connection with existing theories covered in this series is not a claim that 'COS replaces existing theories.' COS repositions existing knowledge such as psychological safety, organizational routines, complex adaptive systems, field theory, cybernetics, behavioral science, and implementation science from the perspective of structural intervention, presenting them as a verifiable research program.
■ Next Preview
On June 3 at 15:00, we will distribute 'Clinical Organizational Science (COS) and Fredrickson's Theory: 3Good1More Is Not a Praise Technique.' It will organize the relationship between positive emotions and cognitive expansion as a theoretical auxiliary line for 3Good1More.
■ About the Journal
This paper has been published in the Organizational Psychology section of 'Frontiers in Psychology,' an international peer-reviewed journal in the field of psychology.
DroR Inc. (Headquarters: Shibuya-ku, Tokyo; CEO: Makoto Yamanaka), a research-practice firm that observes and designs the 'invisible interaction structures' of organizations based on complexity science and neuroscience, has published a paper titled 'Clinical Organizational Science: An Integrative Framework for Structural Intervention in Complex Organizations' in the Organizational Psychology section of the international journal 'Frontiers in Psychology', with CEO Makoto Yamanaka as the lead author.
An English news release about this paper has been distributed via EurekAlert!, and the overall problem statement of COS has also been introduced on the overseas science news site Phys.org. This release organizes the insights of Kandel and Damasio as auxiliary lines for reading neuroscience as an explanatory layer, not as neural measurement.
This release is part of the Clinical Organizational Science (COS) explanatory series distributed from May 7 to June 5. This installment covers Kandel's neuroplasticity, Damasio's somatic marker hypothesis, and COS. Based on the boundary clarified in #5 that 'COS does not perform neural measurement or neural stimulation,' it organizes how to read neuroscience insights as theoretical auxiliary lines.
■ Fixed Definition of Clinical Organizational Science (COS)
Clinical Organizational Science (COS) is a framework that integrates complexity science, neuroscience, organizational psychology, and behavioral science to theorize the interaction structures that actively reproduce the stable state of an organization and to intervene in those structures. COS views organizational change not as 'individual behavioral change' but as 'a transition of organizational attractors,' and presents Field Gradient Theory, Loop Conversion Design, and Neural Base Design as core techniques. It proposes the concept of an 'emergence bridge' to connect individual habituation with organizational-level change.
■ The Role of Neuroscience in COS
COS introduces neuroscience into organizational intervention. However, this is not about measuring employees' brain activity or manipulating neural states. COS does not use EEG, fMRI, neural stimulation, or pharmacological interventions.
Neuroscience in COS is a theoretical framework for explaining behavioral self-sustainability, habit formation, somatic awareness, trust building, and motivational persistence. Neuroscience functions not to reduce organizational phenomena to neural activity, but as a coherence layer to align with the design of behavioral practices.
■ Kandel's Neuroplasticity and Habit Formation
Kandel's research on neuroplasticity showed that repeated experiences or behaviors are involved in changes in neural connections. COS uses this insight to explain the importance of habit formation in organizational change.
A single training session, a single policy announcement, or a single one-on-one design is unlikely to make behavior self-sustaining. By embedding new interaction patterns into daily, weekly, and monthly organizational rhythms and repeating them, individual-level behaviors become more automated and are more likely to be carried into the interaction level.
A conceptual diagram connecting the neuroscientific insights of Kandel and Damasio to COS's neuroscience-informed explanatory layer. It repositions neuroplasticity and the somatic marker hypothesis as auxiliary lines for explaining habit formation, somatic awareness, and motivational persistence, rather than as neural measurement or stimulation.
■ Damasio's Somatic Marker Hypothesis and Somatic Check-ins
Damasio's somatic marker hypothesis is an important theory showing that bodily states are involved in decision-making and judgment. COS connects this perspective to the Somatic Awareness Axis of Neural Base Design.
In organizations, stress, discomfort, tension, fatigue, and relationship problems can manifest as bodily states before being verbalized. Structured somatic check-ins are a practice for recognizing these states early and treating them as resources for collective sensemaking.
■ What COS Inherits from Neuroscience and What It Does Not Claim
Perspective
Usage in COS
What COS Does Not Claim
Neuroplasticity
Explanation of why repetitive behavior has self-sustainability
Does not claim to have directly measured neural changes within the organization
Somatic Marker Hypothesis
Theoretical auxiliary line for somatic check-ins
Does not claim to explain decision-making solely by bodily states
Social Bonding
Auxiliary explanation for gratitude sharing and trust building
Does not claim to have measured specific neurotransmitter changes within the organization
Reward Prediction
Explains motivational persistence of predictable organizational rhythms
Does not claim to manipulate neural rewards
■ Ethical Boundaries
What COS intervenes in is not the neural processes themselves, but the behavioral and social conditions in which neural processes unfold. Interaction structures, feedback architecture, habitual practices, and organizational rhythms are the targets of intervention.
This distinction is essential for the ethical soundness of COS.
■ Comment from CEO Makoto Yamanaka
As long as we use the word 'neuroscience,' the risk of misunderstanding is unavoidable. That is precisely why we repeatedly clarify that COS does not perform neural measurement or neural stimulation.
What we deal with are the behavioral practices and interaction structures that are repeated within organizations. Neuroscience is an auxiliary line for explaining why that design makes sense, not a technology for manipulating employees' brains.
■ Positioning of This Release: Theoretical Organization as Conceptual Analysis
This paper is a theoretical proposal published as a Conceptual Analysis. It does not claim that each COS technique has completed effectiveness verification at this point. It presents a theoretical framework for integrating existing dispersed scientific knowledge and reframing organizational change as a problem of structural intervention, along with propositions that should be verified or falsified in the future.
Therefore, the connection with existing theories covered in this series is not a claim that 'COS replaces existing theories.' COS repositions existing knowledge such as psychological safety, organizational routines, complex adaptive systems, field theory, cybernetics, behavioral science, and implementation science from the perspective of structural intervention, presenting them as a verifiable research program.
■ Next Preview
On June 3 at 15:00, we will distribute 'Clinical Organizational Science (COS) and Fredrickson's Theory: 3Good1More Is Not a Praise Technique.' It will organize the relationship between positive emotions and cognitive expansion as a theoretical auxiliary line for 3Good1More.
■ About the Journal
This paper has been published in the Organizational Psychology section of 'Frontiers in Psychology,' an international peer-reviewed journal in the field of psychology.
FAQ
What types of organizations can COS be applied to?
Theoretically applicable to any organization, especially those with complex interaction structures.
Has the effectiveness of COS been validated?
Currently at the theoretical proposal stage; empirical validation is a future research task.
Where is DroR Inc. located?
Shibuya-ku, Tokyo.