2 Indicators of Immune Infertility: Doctor Warns Blind Injections Increase Body Burden
As immune infertility becomes a hot topic online, a doctor warns that blindly using high-dose immunomodulators can increase physical burden. Two key indicators are suggested: recurrent early miscarriage (2+ times) and failed implantation of normal embryos. Seeking rheumatology help is advised.
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- 📰 Published: June 11, 2026 at 12:58
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(Central News Agency reporter Chen Jieling, Taipei 11th) Immune infertility has become a topic on social media. Doctors remind that the autoimmune system is very dynamic, and blindly using high-dose immunomodulators can actually increase the body's burden. Indicators such as more than two early miscarriages or failed implantation of normal embryos should prompt seeking medical assistance.
Many women trying to conceive have experienced the heavy blow of failed IVF implantation or miscarriage, leading to extreme anxiety and suspicion that they have an immune problem. Dr. Lu Junji, a rheumatologist at Yi Yun Medical Reproduction Center, reminded in a press release today that the actual proportion of clinical immune infertility is "not as high as imagined," and some data online has been over-interpreted.
Dr. Lu proposed clear clinical consultation evaluation criteria. If a woman meets the two typical indicators of "recurrent early miscarriage more than 2 times, or one unexplained fetal arrest after 10 weeks" and "embryos confirmed normal by genetic testing (PGT-A) with a good endometrial environment, yet still experiencing repeated implantation failure," it is recommended to seek help from a rheumatology department.
Dr. Lu emphasized that the autoimmune system is very dynamic. Staying up late, catching a cold, seasonal changes, and even menstruation can cause fluctuations in blood test values, which does not necessarily mean an immune disease. If the values are only temporary physiological fluctuations and do not truly meet diagnostic criteria, blindly using anticoagulants or high-dose immunomodulators can increase the risk of bleeding, causing unnecessary physical burden on the mother and fetus.
He explained that the immune factors that truly affect pregnancy clinically usually refer to "systemic autoimmune diseases" that are strictly defined medically and cause inflammatory reactions in the body, such as systemic lupus erythematosus (SLE). This is completely different from the temporary fluctuations of single immune cells like NK cells that are hotly discussed online. Do not blindly chase fluctuations in single cell values discussed online.
Dr. Lu pointed out that the population most susceptible to systemic lupus erythematosus is women of childbearing age between 20 and 40. Many patients with latent disease are unaware of their condition before trying to conceive. In such patients with autoimmune diseases, because their autoantibodies are abnormally hyperactive, they may mistakenly attack the embryo as a foreign object or cause microvascular thrombosis, preventing the fertilized egg from implanting.
Dr. Lu said that a 37-year-old woman with high-quality embryos and normal preimplantation genetic screening was referred to the rheumatology department after failed embryo implantation. A complete blood evaluation unexpectedly screened her for lupus erythematosus. The patient subsequently received about one year of medical treatment until her disease activity stabilized before she could restart a safe pregnancy process.
He stated that ovarian function naturally declines after age 35, which is a biological inevitability. When facing fertility challenges, a rational approach is to maintain a good routine and physical and mental state. Through team collaboration between the reproductive department and the rheumatology department, first rule out uterine environment and embryo factors, then conduct immune blood tests under normal conditions for comparison, to avoid falling into the anxiety of blind medication use. (Editor: Wu Surou) 1150611
Many women trying to conceive have experienced the heavy blow of failed IVF implantation or miscarriage, leading to extreme anxiety and suspicion that they have an immune problem. Dr. Lu Junji, a rheumatologist at Yi Yun Medical Reproduction Center, reminded in a press release today that the actual proportion of clinical immune infertility is "not as high as imagined," and some data online has been over-interpreted.
Dr. Lu proposed clear clinical consultation evaluation criteria. If a woman meets the two typical indicators of "recurrent early miscarriage more than 2 times, or one unexplained fetal arrest after 10 weeks" and "embryos confirmed normal by genetic testing (PGT-A) with a good endometrial environment, yet still experiencing repeated implantation failure," it is recommended to seek help from a rheumatology department.
Dr. Lu emphasized that the autoimmune system is very dynamic. Staying up late, catching a cold, seasonal changes, and even menstruation can cause fluctuations in blood test values, which does not necessarily mean an immune disease. If the values are only temporary physiological fluctuations and do not truly meet diagnostic criteria, blindly using anticoagulants or high-dose immunomodulators can increase the risk of bleeding, causing unnecessary physical burden on the mother and fetus.
He explained that the immune factors that truly affect pregnancy clinically usually refer to "systemic autoimmune diseases" that are strictly defined medically and cause inflammatory reactions in the body, such as systemic lupus erythematosus (SLE). This is completely different from the temporary fluctuations of single immune cells like NK cells that are hotly discussed online. Do not blindly chase fluctuations in single cell values discussed online.
Dr. Lu pointed out that the population most susceptible to systemic lupus erythematosus is women of childbearing age between 20 and 40. Many patients with latent disease are unaware of their condition before trying to conceive. In such patients with autoimmune diseases, because their autoantibodies are abnormally hyperactive, they may mistakenly attack the embryo as a foreign object or cause microvascular thrombosis, preventing the fertilized egg from implanting.
Dr. Lu said that a 37-year-old woman with high-quality embryos and normal preimplantation genetic screening was referred to the rheumatology department after failed embryo implantation. A complete blood evaluation unexpectedly screened her for lupus erythematosus. The patient subsequently received about one year of medical treatment until her disease activity stabilized before she could restart a safe pregnancy process.
He stated that ovarian function naturally declines after age 35, which is a biological inevitability. When facing fertility challenges, a rational approach is to maintain a good routine and physical and mental state. Through team collaboration between the reproductive department and the rheumatology department, first rule out uterine environment and embryo factors, then conduct immune blood tests under normal conditions for comparison, to avoid falling into the anxiety of blind medication use. (Editor: Wu Surou) 1150611
FAQ
What are the 2 main indicators of immune infertility?
Recurrent early miscarriage (2+ times) or fetal arrest after 10 weeks, and repeated implantation failure with normal embryos.
What are the risks of blind immunotherapy?
Increased bleeding risk and unnecessary burden on mother and fetus.
What immune diseases truly affect pregnancy?
Systemic autoimmune diseases like systemic lupus erythematosus (SLE).