Joint Research with Tokyo University of Technology Discovers Fucoxanthin from Marine Microalga Solaris Suppresses SASP (Senescence-Associated Secretory Phenotype)
Key facts
- Joint Research with Tokyo University of Technology Discovers Fucoxanthin from Marine Microalga Solaris Suppresses SASP (Senescence-Associated Secretory Phenotype)
- Saikureact, in collaboration with Tokyo University of Technology, has discovered that fucoxanthin derived from the marine microalga Fistulifera solaris suppresses SASP—where aging cells secrete inflammatory substances. The compound significantly inhibited IL-6 and MCP-1, showing promise as a novel anti-aging ingredient.
- Source: PR Times
- Date: June 15, 2026
Direct answer
Saikureact, in collaboration with Tokyo University of Technology, has discovered that fucoxanthin derived from the marine microalga Fistulifera solaris suppresses SASP—where aging cells secrete inflammatory substances. The compound significantly inhibited IL-6 and MCP-1, showing promise as a novel anti-aging ingredient.
- Citation
- Joint Research with Tokyo University of Technology Discovers Fucoxanthin from Marine Microalga Solaris Suppresses SASP (Senescence-Associated Secretory Phenotype) (June 15, 2026), PR Times
- Source
- PR Times
- Date
- June 15, 2026
Saikureact, in collaboration with Tokyo University of Technology, has discovered that fucoxanthin derived from the marine microalga Fistulifera solaris suppresses SASP—where aging cells secrete inflammatory substances. The compound significantly inhibited IL-6 and MCP-1, showing promise as a novel anti-aging ingredient.
📋 Article Processing Timeline
- 📰 Published: June 15, 2026 at 21:00
- 🔍 Collected: June 16, 2026 at 00:41 (3h 41m after Published)
- 🤖 AI Analyzed: June 16, 2026 at 00:50 (8 min after Collected)
【Research Background and Objectives】
SASP (Senescence-Associated Secretory Phenotype) refers to the phenomenon where aged cells secrete inflammatory substances such as cytokines. This secretion accelerates aging in neighboring cells, causes chronic inflammation and skin structure degradation, leading to visible signs of aging such as wrinkles and sagging. These effects are exacerbated by ultraviolet radiation (UVB), making SASP a key factor in photoaging. This study focused on fucoxanthin contained in 'Solarina® Extract' derived from the microalga Fistulifera solaris, evaluating its impact on SASP factors in epidermal cells.
【Research Results】
UV irradiation increased levels of inflammatory markers IL-6 and MCP-1, as well as the proteolytic enzyme MMP-3. However, the addition of fucoxanthin suppressed these increases, regardless of UV exposure. The suppression of IL-6 and MCP-1 was particularly significant. In contrast, the effect on MMP-1 was limited. Additionally, a trend toward increased expression of involucrin—a protein involved in skin maturation—was observed.
【Discussion】
The results demonstrate that fucoxanthin suppresses the expression of SASP factors that trigger inflammation and skin matrix degradation. This suggests it may help break the cycle of aging and support the maintenance of healthy skin, including improved barrier function.
【Conclusion】
Fucoxanthin shows potential to effectively combat both intrinsic aging and photoaging, positioning it as a promising new anti-aging ingredient for future applications.
【Glossary】
SASP: Phenomenon where senescent cells secrete inflammatory substances
UVB: Ultraviolet radiation responsible for skin aging
Fucoxanthin: Functional compound derived from algae
IL-6/MCP-1: Substances that induce inflammation
MMP: Enzyme that degrades skin collagen
Involucrin: Protein involved in skin barrier formation
Diatom 'Solaris' is characterized by high fucoxanthin content
Solaris is notable for its exceptionally high fucoxanthin content compared to macroalgae. Previously considered a rare material due to difficulties in mass production, we have now established a domestic cultivation and extraction process, enabling end-to-end production. We aim to build a sustainable, low-environmental-impact supply chain for domestically produced ingredients.
Japan Society of Cosmetic Science Conference Schedule
【Event Dates】
June 25 (Thu) and 26 (Fri), 2026
View details
【Venue】
Asahi Hall, Yurakucho
2-5-1 Yurakucho, Chiyoda-ku, Tokyo
Presentation Location: 11th Floor Exhibition Hall P03
Poster Session: Active Ingredients, Mechanisms, and Skin/Hair Responses
June 25 (Thu), 12:20–13:20
Presentation Title: Suppression of SASP in Epidermal Cells by Fucoxanthin
Collaborating Institution: Professor Masanori Yoshida, Laboratory of Skin Physiology, Department of Applied Bioscience, Tokyo University of Technology
■ Booth #22 (11th Floor): We will provide explanations and samples of Solarina® Extract.
【Company Overview】
Our pursuit of convenient lifestyles has led to serious environmental challenges. To pass a livable world to the next 100 years, we must address these issues.
Small changes in awareness by each of us can take one step forward in environmental protection.
We aim to develop and propose alternative materials through microalgae to reduce environmental impact and build a sustainable future.
This is our mission.
In 3, 5, and 10 years, we will create a society where healthy living coexists with the Earth.
【Business Activities】
• Manufacturing and sales of low-environmental-impact raw materials using marine microalgae
• Planning, manufacturing, and sales of consumer goods using algal-derived ingredients
● Saikureact is a raw material manufacturer that utilizes J-POWER's marine microalgal cultivation technology to produce low-impact, domestically sourced ingredients.
View details
■ Sustainable Actions
team530 (Zero Waste)
We conduct regular beach cleanups at Chigasaki Coast.
We also share information on environmental issues via Instagram. Please follow us!
https://www.instagram.com/team530_japan/
SASP (Senescence-Associated Secretory Phenotype) refers to the phenomenon where aged cells secrete inflammatory substances such as cytokines. This secretion accelerates aging in neighboring cells, causes chronic inflammation and skin structure degradation, leading to visible signs of aging such as wrinkles and sagging. These effects are exacerbated by ultraviolet radiation (UVB), making SASP a key factor in photoaging. This study focused on fucoxanthin contained in 'Solarina® Extract' derived from the microalga Fistulifera solaris, evaluating its impact on SASP factors in epidermal cells.
【Research Results】
UV irradiation increased levels of inflammatory markers IL-6 and MCP-1, as well as the proteolytic enzyme MMP-3. However, the addition of fucoxanthin suppressed these increases, regardless of UV exposure. The suppression of IL-6 and MCP-1 was particularly significant. In contrast, the effect on MMP-1 was limited. Additionally, a trend toward increased expression of involucrin—a protein involved in skin maturation—was observed.
【Discussion】
The results demonstrate that fucoxanthin suppresses the expression of SASP factors that trigger inflammation and skin matrix degradation. This suggests it may help break the cycle of aging and support the maintenance of healthy skin, including improved barrier function.
【Conclusion】
Fucoxanthin shows potential to effectively combat both intrinsic aging and photoaging, positioning it as a promising new anti-aging ingredient for future applications.
【Glossary】
SASP: Phenomenon where senescent cells secrete inflammatory substances
UVB: Ultraviolet radiation responsible for skin aging
Fucoxanthin: Functional compound derived from algae
IL-6/MCP-1: Substances that induce inflammation
MMP: Enzyme that degrades skin collagen
Involucrin: Protein involved in skin barrier formation
Diatom 'Solaris' is characterized by high fucoxanthin content
Solaris is notable for its exceptionally high fucoxanthin content compared to macroalgae. Previously considered a rare material due to difficulties in mass production, we have now established a domestic cultivation and extraction process, enabling end-to-end production. We aim to build a sustainable, low-environmental-impact supply chain for domestically produced ingredients.
Japan Society of Cosmetic Science Conference Schedule
【Event Dates】
June 25 (Thu) and 26 (Fri), 2026
View details
【Venue】
Asahi Hall, Yurakucho
2-5-1 Yurakucho, Chiyoda-ku, Tokyo
Presentation Location: 11th Floor Exhibition Hall P03
Poster Session: Active Ingredients, Mechanisms, and Skin/Hair Responses
June 25 (Thu), 12:20–13:20
Presentation Title: Suppression of SASP in Epidermal Cells by Fucoxanthin
Collaborating Institution: Professor Masanori Yoshida, Laboratory of Skin Physiology, Department of Applied Bioscience, Tokyo University of Technology
■ Booth #22 (11th Floor): We will provide explanations and samples of Solarina® Extract.
【Company Overview】
Our pursuit of convenient lifestyles has led to serious environmental challenges. To pass a livable world to the next 100 years, we must address these issues.
Small changes in awareness by each of us can take one step forward in environmental protection.
We aim to develop and propose alternative materials through microalgae to reduce environmental impact and build a sustainable future.
This is our mission.
In 3, 5, and 10 years, we will create a society where healthy living coexists with the Earth.
【Business Activities】
• Manufacturing and sales of low-environmental-impact raw materials using marine microalgae
• Planning, manufacturing, and sales of consumer goods using algal-derived ingredients
● Saikureact is a raw material manufacturer that utilizes J-POWER's marine microalgal cultivation technology to produce low-impact, domestically sourced ingredients.
View details
■ Sustainable Actions
team530 (Zero Waste)
We conduct regular beach cleanups at Chigasaki Coast.
We also share information on environmental issues via Instagram. Please follow us!
https://www.instagram.com/team530_japan/
FAQ
Where is fucoxanthin sourced from?
It is mainly found in brown algae and microalgae, with Solaris known for its exceptionally high content.
Why is SASP inhibition beneficial for skin?
SASP accelerates aging in neighboring cells, so its inhibition helps prevent wrinkles and sagging.
What products use Solarina® Extract?
It is expected to be used in anti-aging skincare and health supplements.