Dentist-Supervised Total Immunity Care Supplement 'THE MENEKI', Caring for Both Oral and Intestinal Environments Simultaneously, Launches on Wednesday, May 6, 2026
botanience Co., Ltd. will release 'THE MENEKI', a total immunity care supplement that simultaneously approaches both oral and intestinal environments, on May 6, 2026. Supervised by a dentist, it features over 20 types of lactic acid bacteria in a sugar-free tablet.
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- 📰 Published: April 15, 2026 at 19:00
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botanience Co., Ltd. (Headquarters: Koto-ku, Tokyo, Representative: Yamato Kataoka) will begin selling the total immunity care supplement "THE MENEKI," which can simultaneously approach both the oral and intestinal environments, on its own EC site starting Wednesday, May 6, 2026. Formulated with carefully selected ingredients including over 20 types of lactic acid bacteria, the subscription plan will be offered at a special initial price of 3,980 yen (4,298 yen including tax).
According to a survey by the Ministry of Health, Labour and Welfare (*1), about 80% of Japanese adults are said to have signs of periodontal disease, increasing interest in improving the oral environment. Recent studies have highlighted the importance of regulating the body as a whole rather than just one part, as the oral cavity and intestines are connected by a common mechanism called mucosal immunity.
Based on this concept, THE MENEKI is a melt-in-mouth tablet-type supplement manufactured in a GMP-certified factory, developed under the supervision of Dr. Mariko Shimura (Vice Director of Shimura Dental Clinic), who has been engaged in oral immunity and dry mouth medical care for many years.
■ Development Background ── Why "Simultaneous Care of Mouth and Gut"?
Around the time I left my previous job, it overlapped with the winter cold season, and I had more opportunities to see commercials for immune-system products, realizing the necessity of strengthening the body's daily immunity. At that time, triggered by a single video, I was made aware that not only the generalized "gut health" but also the immune approach from the oral cavity is important, and I began reading domestic and international literature.
As I investigated, I found that overseas, particularly in the United States, the field of oral care and intestinal immunity care has already developed and matured. On the other hand, oral preventive medicine in Japan is still lagging, and I felt great potential in combining these two.
Furthermore, Japanese people have a deeply rooted culture and custom of nurturing things from childhood, and I thought the concept of nurturing bacteria inside one's own body is an extension of that, convinced that it would suit the Japanese temperament.
■ Three Features of the Product
1. Unique ingredient design that simultaneously supports oral care and gut health
Formulated with carefully selected ingredients such as over 20 types of lactic acid bacteria including Lactobacillus K-12 to regulate the oral environment and spore-bearing lactic acid bacteria (Sporlac), as well as 5 types of Bifidobacterium and butyric acid bacteria to support the intestinal environment. Including immune support ingredients like β-glucan, it integrates oral care, gut health, and immune support into a single supplement. It is designed to combine live bacteria that arrive alive with heat-treated lactic acid bacteria, leveraging their respective characteristics.
2. Thorough commitment to quality
THE MENEKI uses no unnecessary additives and is domestically produced in a GMP-certified factory approved by the Ministry of Health, Labour and Welfare. In addition, Dr. Mariko Shimura, who has long been engaged in oral immunity and dry mouth medical care, supervised the ingredient design.
The combination and balance of ingredients are designed from the perspective of bacterial balance in the oral cavity and mucosal immunity. We propose a new oral self-care habit that can be practiced every day.
3. Sugar-free, melt-in-mouth tablets easy to take even before bedtime
We adopted a tablet shape that can be dissolved in the mouth without water. Because it is sugar-free, it can be taken after brushing teeth before bed, and it continues to work during the night when saliva secretion tends to decrease and immunity drops.
Also, by dissolving slowly in the mouth, it is designed so that oral care ingredients like Lactobacillus K-12 and spore-bearing lactic acid bacteria (Sporlac) easily reach the oral cavity. Being able to take it easily regardless of time or place is also considered from the characteristic of supplements, which is important to continue every day.
■ Main Ingredients (per 2 tablets)
Lactobacillus K-12 (Streptococcus salivarius K12), Sporlac (Spore-bearing lactic acid bacteria), Lactobacillus reuteri, Bifidobacterium BB536, Butyric acid bacteria, Lactic acid bacteria premix, Inulin, Fructooligosaccharide, β-glucan (derived from baker's yeast), Propolis extract, Vitamin D3, Vitamin C, Vitamin B6, Vitamin B12, Zinc-containing yeast
■ Supervising Doctor's Comment
Vice Director of Shimura Dental Clinic, Dry Mouth & Bad Breath Outpatient Clinic
Dentist Pioneering Oral Health
Dr. Mariko Shimura
[Career]
Graduated from the School of Dentistry, Showa University in 1988.
After working in the Department of Endodontics at the same university, she worked in the Department of Oral and Maxillofacial Surgery at NTT Medical Center Tokyo for 16 years from 1999 to 2015. Launched the Dry Mouth Outpatient Clinic in 2000 and has been treating dry mouth and Sjögren's syndrome as a dry mouth project leader. Furthermore, in 2009, she established a specialized oral care outpatient clinic...
According to a survey by the Ministry of Health, Labour and Welfare (*1), about 80% of Japanese adults are said to have signs of periodontal disease, increasing interest in improving the oral environment. Recent studies have highlighted the importance of regulating the body as a whole rather than just one part, as the oral cavity and intestines are connected by a common mechanism called mucosal immunity.
Based on this concept, THE MENEKI is a melt-in-mouth tablet-type supplement manufactured in a GMP-certified factory, developed under the supervision of Dr. Mariko Shimura (Vice Director of Shimura Dental Clinic), who has been engaged in oral immunity and dry mouth medical care for many years.
■ Development Background ── Why "Simultaneous Care of Mouth and Gut"?
Around the time I left my previous job, it overlapped with the winter cold season, and I had more opportunities to see commercials for immune-system products, realizing the necessity of strengthening the body's daily immunity. At that time, triggered by a single video, I was made aware that not only the generalized "gut health" but also the immune approach from the oral cavity is important, and I began reading domestic and international literature.
As I investigated, I found that overseas, particularly in the United States, the field of oral care and intestinal immunity care has already developed and matured. On the other hand, oral preventive medicine in Japan is still lagging, and I felt great potential in combining these two.
Furthermore, Japanese people have a deeply rooted culture and custom of nurturing things from childhood, and I thought the concept of nurturing bacteria inside one's own body is an extension of that, convinced that it would suit the Japanese temperament.
■ Three Features of the Product
1. Unique ingredient design that simultaneously supports oral care and gut health
Formulated with carefully selected ingredients such as over 20 types of lactic acid bacteria including Lactobacillus K-12 to regulate the oral environment and spore-bearing lactic acid bacteria (Sporlac), as well as 5 types of Bifidobacterium and butyric acid bacteria to support the intestinal environment. Including immune support ingredients like β-glucan, it integrates oral care, gut health, and immune support into a single supplement. It is designed to combine live bacteria that arrive alive with heat-treated lactic acid bacteria, leveraging their respective characteristics.
2. Thorough commitment to quality
THE MENEKI uses no unnecessary additives and is domestically produced in a GMP-certified factory approved by the Ministry of Health, Labour and Welfare. In addition, Dr. Mariko Shimura, who has long been engaged in oral immunity and dry mouth medical care, supervised the ingredient design.
The combination and balance of ingredients are designed from the perspective of bacterial balance in the oral cavity and mucosal immunity. We propose a new oral self-care habit that can be practiced every day.
3. Sugar-free, melt-in-mouth tablets easy to take even before bedtime
We adopted a tablet shape that can be dissolved in the mouth without water. Because it is sugar-free, it can be taken after brushing teeth before bed, and it continues to work during the night when saliva secretion tends to decrease and immunity drops.
Also, by dissolving slowly in the mouth, it is designed so that oral care ingredients like Lactobacillus K-12 and spore-bearing lactic acid bacteria (Sporlac) easily reach the oral cavity. Being able to take it easily regardless of time or place is also considered from the characteristic of supplements, which is important to continue every day.
■ Main Ingredients (per 2 tablets)
Lactobacillus K-12 (Streptococcus salivarius K12), Sporlac (Spore-bearing lactic acid bacteria), Lactobacillus reuteri, Bifidobacterium BB536, Butyric acid bacteria, Lactic acid bacteria premix, Inulin, Fructooligosaccharide, β-glucan (derived from baker's yeast), Propolis extract, Vitamin D3, Vitamin C, Vitamin B6, Vitamin B12, Zinc-containing yeast
■ Supervising Doctor's Comment
Vice Director of Shimura Dental Clinic, Dry Mouth & Bad Breath Outpatient Clinic
Dentist Pioneering Oral Health
Dr. Mariko Shimura
[Career]
Graduated from the School of Dentistry, Showa University in 1988.
After working in the Department of Endodontics at the same university, she worked in the Department of Oral and Maxillofacial Surgery at NTT Medical Center Tokyo for 16 years from 1999 to 2015. Launched the Dry Mouth Outpatient Clinic in 2000 and has been treating dry mouth and Sjögren's syndrome as a dry mouth project leader. Furthermore, in 2009, she established a specialized oral care outpatient clinic...