Introducing 'QWEENTOX Capsule Bio Cream' Formulated with the World's First Topical Botulinum Toxin-Derived Ingredient 'Biotox-LC'! The Highly Anticipated Moisturizing Cream by Users Starts Sales on TV Tokyo

*Officially the world's first formulation in a capsule cream *As of March 29, 2026 Bizvolante Co., Ltd. (Location: Shibuya-ku, Tokyo; CEO: Chizu Oikawa) released the "QWEENTOX Brand" on Friday, July 5, 2024. This brand is the first in Japan to formulate Biotox-LC, an ingredient developed by CoSeed Biopharm (Location: Heungdeok-gu, Cheongju, Chungbuk), a Korean ingredient development company boasting high-functional ingredients and advanced technology. The era where botulinum toxin-derived ingredients can be used as cosmetics has arrived, making it a hot topic, especially in TV shopping. In particular, the first product in the series, "Perfect Bio Serum," sold out its prepared stock in just 10 minutes after broadcasting began on TV Tokyo. Following this, it recorded such a massive response that there was an approximately 3-month waiting list, attracting the attention of many viewers. (Broadcast on November 4, 2024) The new "Capsule Bio Cream" was born against the backdrop of such proven success, and even greater expectations are placed upon it as a new item. It is a product officially recognized by CoSeed Biopharm, pioneering the global market by formulating Biotox-LC and the advanced ingredient KTP1 Filaggrin, which was just registered in Japan in June 2025, into a cream. *Botulinum toxin-derived ingredient Biotox-LC: Water, BG, 1,2-Hexanediol, Hydrogenated Lecithin, Caprylic/Capric Triglyceride, Sodium Palmitoyl Sarcosinate, Disodium EDTA, Synthetic Recombinant Oligopeptide-91 Botulinum Polypeptide-1. Purpose of formulation: Firmness/radiance ingredient, skin conditioning ingredient *Officially the world's first formulation in a capsule cream Topical Botulinum Toxin-Derived Ingredient Biotox-LC *Image Biotox-LC is an ingredient developed through thorough research on the mechanism of how skin loses firmness. It is a firmness and radiance ingredient produced via biotechnology, extracting only the active components of botulinum toxin-derived ingredients that previously could only be used in specialized beauty clinics. For the first time in the world, this ingredient was commercialized in the form of a capsule cream. [World's First Formulation] Advanced Ingredient KTP1 Filaggrin *KTP1 Filaggrin: Synthetic Recombinant (Methionyl Synthetic Human Oligopeptide-194 Methionyl Synthetic Human Recombinant Polypeptide-170) *Purpose of formulation: Firmness, moisturizing *Image: Illustration *Officially the world's first formulation in a capsule cream *As of March 29, 2026 Furthermore, this cream formulates "KTP1 Filaggrin," an ingredient focused on filaggrin. Filaggrin is known as an important protein related to skin moisture and is said to play a role in maintaining the moisture balance of the stratum corneum. This ingredient, KTP1-Filaggrin, includes an ingredient designed through synthetic peptide technology: Synthetic Recombinant (Methionyl Synthetic Human Oligopeptide-194 Methionyl Synthetic Human Recombinant Polypeptide-170), developed focusing on the skin's moisture environment. It prevents dryness while keeping the skin moist, leading to a smooth and healthy skin impression. Formulated with Sturgeon-Derived PDRN *Sturgeon-derived PDRN: DNA-Na, Purpose of formulation: Firmness *Image: Illustration It also formulates DNA ingredients derived from sturgeon. Known as PDRN (Poly Deoxyribonucleotide), it is an ingredient that has gained attention in skincare in recent years. Generally, PDRN is known as a DNA ingredient derived from fish, but this product adopts raw materials derived from sturgeon. Focusing on stability and affinity, it is designed to be easily incorporated into daily skincare. In addition, it formulates special ingredients curated by QWEENTOX. Fuco Skin - Moisturizing Ingredient A moisturizing ingredient based on low-molecular-weight fucoidan derived from seaweed. It moisturizes the skin, keeping it fresh and dewy. MadeWhite™ - Skin Conditioning Ingredient A skin conditioning ingredient formulated with Centella Asiatica-derived component (Madecassoside). It keeps the skin healthy while conditioning it to a bright and even impression. Human Umbilical Cord Blood-Derived Stem Cell Culture Medium - Firming Ingredient A skin-conditioning design that focuses on the skin's moisture environment by formulating a culture medium containing ingredients derived from stem cells. It leads to a firm, radiant, and smooth skin impression. Ice Crystal - Moisturizing Ingredient An ingredient derived from the Ice Plant, a plant capable of surviving even in dry environments. It moisturizes the skin while protecting it from dryness caused by external environments, adjusting it to a healthy state. IBR-Snowflake - Firming Ingredient A firming ingredient inspired by the dormancy mechanism of plants. It conditions the skin's state while leading to a firm and smooth impression. Product Handling: Azabu Store Co., Ltd. Product Sales Website: https://azabustore.co.jp/ Program Production Planning: Bizvolante Co., Ltd. Company Website: https://bizvolante...