TCB Dr. Keisuke Matsumura et al.'s Paper on Intravenous Anesthesia in Aesthetic Surgery Published in 'Aesthetic Plastic Surgery'. Prospective Study Confirms 'High Satisfaction, Low Intraoperative Memory, Rapid Recovery'.

Dr. Keisuke Matsumura of TCB Tokyo Central Aesthetic Surgery (Chairman: Hiroo Teranishi, hereinafter 'TCB'), a cosmetic clinic with 101 locations nationwide as of June 2026, conducted a prospective study of 135 consecutive cases using depth-adjusted intravenous anesthesia (UMEDA protocol) in office-based aesthetic surgery. The results were published as 'Safety of Depth-Adjusted Intravenous Anesthesia in Office-Based Aesthetic Surgery: A One-Month Prospective Study of 135 Consecutive Cases'. In addition to the absence of major respiratory or circulatory events, the study systematically evaluated patient experience indicators such as patient satisfaction, intraoperative memory, and recovery time. The findings were published in May 2026 in the aesthetic surgery journal 'Aesthetic Plastic Surgery'. Paper: 'Safety of Depth-Adjusted Intravenous Anesthesia in Office-Based Aesthetic Surgery: A One-Month Prospective Study of 135 Consecutive Cases' Paper Title: Safety of Depth-Adjusted Intravenous Anesthesia in Office-Based Aesthetic Surgery: A One-Month Prospective Study of 135 Consecutive Cases Journal: Aesthetic Plastic Surgery Publication Date: May 2026 Authors: Matsumura K., Tamura T., Okumura K., et al. DOI: 10.1007/s00266-026-05922-z URL: https://link.springer.com/article/10.1007/s00266-026-05922-z Background Intravenous anesthesia is frequently used in office-based aesthetic surgery to balance intraoperative comfort and rapid recovery. While large retrospective datasets suggest low complication rates, prospective data on patient-reported outcomes under a standardized depth-adjusted protocol have been limited. Therefore, this study prospectively evaluated the safety, patient satisfaction, intraoperative memory, and recovery associated with the specialist-led 'UMEDA protocol'. Methods A single-center prospective observational study was conducted on 135 consecutive adult patients who underwent office-based aesthetic surgery between May 1 and May 31, 2025. According to the 'UMEDA (Ultra-safe Method for Elective Depth-adjusted Anesthesia) protocol', blood pressure, heart rate, and pulse oximetry were monitored at 5-minute intervals. Propofol was the primary anesthetic agent (133/135 cases), with midazolam used only for patients with a history of allergy to propofol components (2/135 cases). The primary endpoint was patient satisfaction (5-point Likert scale). Secondary endpoints included intraoperative memory, recovery time, and major cardiopulmonary events. Two pre-specified multivariate logistic regressions were used to examine predictors of (1) high satisfaction (score = 5) and (2) sustained memory. Results No major cardiopulmonary events (significant respiratory or circulatory events) occurred during the study period. The median satisfaction score was 5 [IQR 4–5], with 68.1% of patients rating it as 5. Regarding intraoperative memory, 38.5% reported 'none', 47.4% reported 'only during induction/awakening', and 14.1% reported 'sustained'. The median recovery time was 22 minutes [13.0–36.0]. In the satisfaction model, female sex independently predicted high satisfaction (aOR 3.31; 95% CI 1.04–10.50; p=0.042). Age, operative time, recovery time, weight-adjusted propofol dose, multi-site surgery, and continuous infusion were not significant factors (all VIF<5). In the memory model, a higher weight-adjusted propofol dose independently reduced the odds of sustained memory (aOR 0.07; 95% CI 0.01–0.67; p=0.021). Sex was not significant (all VIF<2). Conclusions In 135 consecutive office-based aesthetic surgery cases managed with the UMEDA protocol, depth-adjusted intravenous anesthesia was safely performed, resulting in very high patient satisfaction, a low incidence of sustained intraoperative memory, and rapid recovery. These results support the safe and effective implementation of specialist-led depth-adjusted intravenous anesthesia in outpatient aesthetic surgery practice and underscore the significance of future multicenter validation. In the field of elective aesthetic surgery, intravenous anesthesia is widely used to achieve both patient comfort and rapid recovery. Meanwhile, social interest in the safety and standardization of anesthesia in outpatient settings is increasing. TCB has previously reported a retrospective study (4,397 cases) validating the safety of intravenous anesthesia in office-based aesthetic surgery (https://prtimes.jp/main/html/rd/p/000000311.000034186.html). The significance of this prospective study lies in its prospective evaluation of 'efficacy (patient experience)'—including patient satisfaction, intraoperative memory, and recovery time—under a standardized protocol, building upon that 'safety foundation'. The study demonstrated safety with no major events, along with high satisfaction, low sustained intraoperative memory, and short recovery time. This provides prospective data supporting the potential to not only 'safely' provide intravenous anesthesia in office-based aesthetic surgery but also to manage the 'quality of patient experience (comfort, memory suppression, recoverability)'. This study is a single-center, short-term prospective study. Future goals include contributing to the establishment of safety standards and educational systems for intravenous anesthesia in the office-based aesthetic surgery field through multicenter validation and operational standardization. Keisuke Matsumura TCB Umeda Osaka Ekimae Clinic https://aoki-tsuyoshi.com/doctor/matsumura_keisuke TCB Umeda Osaka Ekimae Clinic 3F K's Square Building, 2-8-15 Sonezaki, Kita-ku, Osaka City, Osaka Prefecture, 530-0057 Phone Appointment: 0120-197-262 https://aoki-tsuyoshi.com/clinic/shinsaibashi/umedaosaka