Notice Regarding Changes in Subsidiaries (Conversion of Non-Consolidated Subsidiary to Consolidated Subsidiary) and Management Structure

Alfresa Holdings has decided to include its non-consolidated subsidiary, ArkMS Inc. (Headquarters: Toshima-ku, Tokyo; President: Akira Mizuo; hereinafter "ArkMS"), which conducts CRO*1 business, within the scope of consolidation. Details are as follows.

1. Reason for the Change in Subsidiary The Alfresa Group has positioned the Total Supply Chain Service (TSCS*5), which provides integrated support from the introduction, development, and manufacturing of pharmaceuticals to logistics, sales, post-marketing surveillance (PMS*4), and last-mile delivery, as a pillar of its business strategy in the "Alfresa Group Medium- to Long-Term Vision"*2 and the "25–27 Medium-Term Management Plan Vision2032 Stage2"*3.

We acquired all shares of ArkMS, which was established through a company split (incorporation-type company split) by INTAGE Healthcare Inc. (Headquarters: Chiyoda-ku, Tokyo; President: Keita Murai), and made it a wholly owned subsidiary in September 2024. As ArkMS is expected to take on a greater role in supporting the development of pharmaceuticals within the TSCS as a CRO, its qualitative importance has increased. Therefore, we have decided to include it as a consolidated subsidiary starting from the first quarter of the fiscal year ending March 2027.

*1 CRO: (Contract Research Organization) An organization that supports a series of tasks related to clinical trials conducted by pharmaceutical companies and research institutions. *2 Reference: Announced May 15, 2023, "Notice Regarding Formulation of Alfresa Group Medium- to Long-Term Vision." *3 Reference: Announced May 15, 2025, "Notice Regarding Formulation of 25–27 Medium-Term Management Plan Vision2032 Stage2." *4 PMS: (Post Marketing Surveillance) Surveys conducted after pharmaceuticals or medical devices are marketed to ensure quality, efficacy, and safety. *5 TSCS: Refers to providing seamless supply chain services by organically utilizing the various functions held by the entire Alfresa Group, from introduction, development, and manufacturing to logistics, sales, post-marketing surveillance, and last-mile delivery.