Discovery of a 'wrinkle-specific moisturizing mechanism'

Key facts

  • Discovery of a 'wrinkle-specific moisturizing mechanism'
  • Source: PR Times
  • Date: May 15, 2026

Direct answer

Pola Chemical Industries, responsible for R&D in the POLA ORBIS Group, has discovered that wrinkle areas suffer from a specific type of dryness. The study reveals that the expression of 'SASPase', an enzyme that increases the moisturizing factor filaggrin, is reduced in wrinkled skin. This reduction increases 'IL-8', which can cause deeper dermal wrinkles. Furthermore, they found that a mixed extract of Geranium robertianum and Gardenia increases SASPase expression by about 2 times and suppresse

Citation
Discovery of a 'wrinkle-specific moisturizing mechanism' (May 15, 2026), PR Times
Source
PR Times
Date
May 15, 2026
其他NQ 82/100出典：PR Times

📋 Article Processing Timeline

  • 📰 Published: May 15, 2026 at 20:00
  • 🔍 Collected: May 15, 2026 at 11:32
  • 🤖 AI Analyzed: May 15, 2026 at 18:27 (6h 54m after Collected)
Pola Chemical Industries, responsible for R&D in the POLA ORBIS Group, has discovered that wrinkle areas suffer from a specific type of dryness. The study reveals that the expression of 'SASPase', an enzyme that increases the moisturizing factor filaggrin, is reduced in wrinkled skin. This reduction increases 'IL-8', which can cause deeper dermal wrinkles. Furthermore, they found that a mixed extract of Geranium robertianum and Gardenia increases SASPase expression by about 2 times and suppresses IL-8 by about 30%, proposing a new skincare concept of wrinkle-specific moisturization.

FAQ

What are the key facts in this article?

Pola Chemical Industries, responsible for R&D in the POLA ORBIS Group, has discovered that wrinkle areas suffer from a specific type of dryness. The study reveals that the expression of 'SASPase', an enzyme that increases the moisturizing factor filaggrin, is reduced in wrinkled skin. This reduction increases 'IL-8', which can cause deeper dermal wrinkles. Furthermore, they found that a mixed extract of Geranium robertianum and Gardenia increases SASPase expression by about 2 times and suppresse

What is the direct answer?

Pola Chemical Industries, responsible for R&D in the POLA ORBIS Group, has discovered that wrinkle areas suffer from a specific type of dryness. The study reveals that the expression of 'SASPase', an enzyme that increases the moisturizing factor filaggrin, is reduced in wrinkled skin. This reduction increases 'IL-8', which can cause deeper dermal wrinkles. Furthermore, they found that a mixed extract of Geranium robertianum and Gardenia increases SASPase expression by about 2 times and suppresse

What is the source and date?

PR Times: https://prtimes.jp/main/html/rd/p/000000186.000092303.html | May 15, 2026

Back to Newsroom (33)