[Renewal] Announcement of Glucola Pro + Hihatsu Sales Launch

## Press Release Information
Title: [Renewal] Announcement of Glucola Pro + Hihatsu Sales Launch
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Body (first 8000 characters): "Glucola Pro + Hihatsu" now features three functional ingredients.

The predecessor to "Glucola Pro + Hihatsu" is a long-selling product that began sales in 2011. While incorporating acacia polyphenols, a flagship product equivalent to our company's Akapoli from acacia, and multivitamins, we have expanded sales as a supplement for knee care.

This time, "Glucola Pro + Hihatsu," which is now being launched, has refreshed its functional ingredients to three components: salmon nasal cartilage-derived proteoglycan, salmon nasal cartilage-derived undenatured type II collagen, N-acetylglucosamine, and Hihatsu-derived piperine. Through this renewal, in addition to the conventional "knee joint and walking support," we have achieved an approach to important new challenges: "muscle maintenance" and "coldness/swelling care."

"Glucola Pro + Hihatsu" is a product that has achieved an "uncompromising evolution," increasing the richness of its ingredients without reducing the amounts of salmon nasal cartilage-derived proteoglycan, salmon nasal cartilage-derived undenatured type II collagen, N-acetylglucosamine, and acacia polyphenols found in the old product "Glucola Pro."

[New Functional Ingredient] Evidence for Hihatsu-derived piperine

The biggest point of this renewal is the inclusion of "Hihatsu-derived piperine." Hihatsu is a plant of the pepper family mainly cultivated in Southeast Asia and India, and has been cultivated and grown wild in Okinawa Main Island, Miyako, and Yaeyama Islands for a long time, used as a spice for pork dishes and Okinawa soba. The addition of this Hihatsu makes it possible to appeal to "cold hands and feet *1" and "evening leg swelling *2," which hinder an active daily life.

*1 Reduces the decrease in skin surface temperature, *2 Temporary swelling that is not pathological

[Added Functionality] Added function to help maintain muscle mass

Regarding the salmon nasal cartilage-derived ingredients that have been included conventionally, by reflecting the latest research reviews, a new claim has been added to support muscle maintenance: "It has been reported to help maintain muscle mass that declines with age for those who feel a decrease in muscle strength in daily life."

Evolved into an easier-to-continue design by reducing the number of tablets

Furthermore, this renewal is not just about changes in functionality. The old product Glucola Pro was designed for a daily intake of 8 tablets, but we sometimes received earnest feedback that "8 tablets a day is a bit too many to take every day." This time, by reviewing the formulation and readjusting excipients, we succeeded in reducing the daily intake to 6 tablets. This change was made without reducing the amounts of functional ingredients or acacia polyphenols, evolving into a form that is easier for customers to continue than ever before. In addition, the container has been refreshed from a bottle to a slim pouch type. This allows for receipt via postal mail (mail service), eliminating the hassle of redelivery, and has been reborn in a form that is more attuned to customers' lifestyles.

Comparison table of renewed products

Old Product

New Product

Product Name

Glucola Pro

Glucola Pro + Hihatsu

Notification Number

G988

J1450

Functional Ingredients

Salmon nasal cartilage-derived proteoglycan, salmon nasal cartilage-derived undenatured type II collagen, N-acetylglucosamine

Salmon nasal cartilage-derived proteoglycan, salmon nasal cartilage-derived undenatured type II collagen, N-acetylglucosamine, Hihatsu-derived piperine

Notification Wording

This product contains salmon nasal cartilage-derived proteoglycan and salmon nasal cartilage-derived undenatured type II collagen. Salmon nasal cartilage-derived proteoglycan and salmon nasal cartilage-derived undenatured type II collagen have been reported to support the improvement of knee movement (walking, bending and extending knees, standing up, squatting, sitting seiza, climbing and descending stairs) in daily life for middle-aged and elderly people (middle-aged and seniors) with discomfort in their knee joints. This product also contains N-acetylglucosamine. N-acetylglucosamine has been reported to improve knee joint discomfort during movement. It is suitable for those concerned about knee joints when walking or climbing and descending stairs.

This product contains salmon nasal cartilage-derived proteoglycan and salmon nasal cartilage-derived undenatured type II collagen. Salmon nasal cartilage-derived proteoglycan and salmon nasal cartilage-derived undenatured type II collagen are reported to support the daily knee joint movement (climbing and descending stairs, walking, squatting, etc.) of healthy middle-aged and elderly people with discomfort in their knee joints and to alleviate discomfort. It has also been reported to help maintain muscle mass that declines with age for those who feel a decrease in muscle strength in daily life. This product also contains N-acetylglucosamine. N-acetylglucosamine has been reported to improve knee joint discomfort during walking and climbing and descending stairs. Furthermore, this product contains Hihatsu-derived piperine.
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