[Presented at the 7th Academic Meeting of the Japan Society of Cosmetic Medicine] Leading Anti-Aging Expert Dr. Sawako Hibino Recommends the Potential of the Internationally Patented New Ingredient 'Minexin®'
flowli LLC announced that its advisory physician, Dr. Sawako Hibino, presented the potential of the new internationally patented anti-aging ingredient 'Minexin®' at the 7th Japan Society of Cosmetic Medicine. The ingredient showed promising multi-faceted benefits for skin and scalp environments.
📋 Article Processing Timeline
- 📰 Published: April 23, 2026 at 18:00
- 🔍 Collected: April 23, 2026 at 09:31
- 🤖 AI Analyzed: April 24, 2026 at 04:28 (18h 56m after Collected)
flowli LLC (Headquarters: Meguro-ku, Tokyo) announces that at the 7th Academic Meeting of the Japan Society of Cosmetic Medicine held on Saturday, April 18, 2026, Dr. Sawako Hibino, our advisory physician, gave a presentation titled 'The Potential of the New Ingredient Minexin®: A Study on Skin and Scalp Functions Based on Case Numbers' during a co-sponsored seminar chaired by Dr. Taro Kono (Professor and Chairman, Department of Plastic Surgery, Tokai University School of Medicine).
The theme of this academic meeting was 'The Pursuit of Ultimate Beauty', and experts from various fields gave multifaceted presentations on approaches from both the inner and outer aspects.
In this presentation, the composite ingredient 'Minexin®' was highlighted as a new approach to age-related changes in the skin and scalp, and the results of studies through basic evaluation and case observation were reported.
In recent years, it has been recognized that complex factors such as microbiome disturbances, declining barrier functions, chronic inflammation, and changes in microcirculation are involved in the background of skin and scalp troubles. Therefore, rather than dealing with a single ingredient, approaches targeting the entire environment are being prioritized.
◼️ About Minexin®
Image of Minexin®'s action on the skin
Minexin® is a composite design ingredient that combines microbiome-derived components (lactic acid, lipoteichoic acid), bio-minerals (calcium, magnesium, potassium, silica, etc.), and plant-derived ingredients. It was developed to maintain the homeostasis of the skin and scalp environment.
◼️ Research and Study Content
In basic evaluations, the following trends were confirmed:
- Proliferation promotion tendency in keratinocytes and fibroblasts (approx. 70% or more)
- Increased expression of barrier-related genes (profilaggrin) (approx. 160%)
- Promotion of hyaluronic acid production
- Suppression tendency of inflammation-related factors (COX-2, PGE2, IL-6)
Additionally, in case observations, the following were suggested:
- Tendency to improve barrier function and moisturizing state in the skin area
- Reduction of inflammatory tendencies
- Tendency to improve hair density and hair diameter in the scalp area
- Tendency to reduce hair loss
These results suggest the possibility that Minexin® acts not as a single function but as a multifaceted approach that works on the entire environment of the skin and scalp.
Based on the findings obtained in this research, Minexin® is expected to be utilized as a new approach in the anti-aging field and cosmetic medicine in the future.
Furthermore, further studies regarding its affinity with the cell-free domain are planned to proceed.
◼️ Presenter's Comment
Dr. Sawako Hibino
'Skin and scalp troubles do not occur due to a single cause but due to a combination of multiple factors. In this presentation, we examined the potential of an approach that focuses on that "entire environment." We intend to continue further verification from a clinical perspective in the future.'
◼️ Company Comment
flowli LLC
'We feel it is deeply meaningful to have been able to widely share the knowledge of basic and clinical observations regarding Minexin® through this academic conference presentation. We will continue product development and information dissemination based on evidence.'
◼️ Dr. Sawako Hibino
General Director, Medical Corporation Koshikai SAWAKO CLINIC x YS
Specially Appointed Associate Professor, Endowed Chair of Future Medical Science, Graduate School of Medicine, Osaka University
Representative Director, International Medical Science Research Society; President, Japan Society of Cosmetic Medicine
Councilor of the Japanese Society for Regenerative Medicine, Certified Physician of the Japanese Society for Regenerative Medicine, Specialist of the Japanese Society of Anti-Aging Medicine. She has served as a Lecturer at the Anti-Aging Research Center of Doshisha University, an Associate Professor at the Faculty of Health and Medical Sciences of Morinomiya University of Medical Sciences, and the Head of the Anti-Aging Medical Science Research Laboratory in the Basic Research Department of the Louis Pasteur Center for Medical Research.
Currently, as a pioneer in anti-aging medicine, she actively engages in advanced medicine, including the latest regenerative medicine, ranging from basic research to clinical research, and is internationally active. She has also garnered attention in media such as television and magazines.
Co-sponsored seminar exhibition venue
◼️ Japan Society of Cosmetic Medicine
The Japan Society of Cosmetic Medicine is an academic organization aimed at researching and disseminating information about cosmetics from a medical perspective based on scientific evidence. With an eye toward improving the QOL of the elderly and applying it to the medical and rehabilitation fields, it works toward the development of the cosmetic medicine field through academic meetings, educational activities, and the establishment of specialized qualification systems.
◼️ PHARMOLOGY Product Introduction
Epiderm Cryo Gel
Intensive Barrier Fix
Nutribalance: White Tab.
Skin Reset Drop
'PHARMOLOGY' is a skincare and haircare line formulated with 'Minexin', a proprietary ingredient born from research applying 10 types of natural minerals and patented technology.
The theme of this academic meeting was 'The Pursuit of Ultimate Beauty', and experts from various fields gave multifaceted presentations on approaches from both the inner and outer aspects.
In this presentation, the composite ingredient 'Minexin®' was highlighted as a new approach to age-related changes in the skin and scalp, and the results of studies through basic evaluation and case observation were reported.
In recent years, it has been recognized that complex factors such as microbiome disturbances, declining barrier functions, chronic inflammation, and changes in microcirculation are involved in the background of skin and scalp troubles. Therefore, rather than dealing with a single ingredient, approaches targeting the entire environment are being prioritized.
◼️ About Minexin®
Image of Minexin®'s action on the skin
Minexin® is a composite design ingredient that combines microbiome-derived components (lactic acid, lipoteichoic acid), bio-minerals (calcium, magnesium, potassium, silica, etc.), and plant-derived ingredients. It was developed to maintain the homeostasis of the skin and scalp environment.
◼️ Research and Study Content
In basic evaluations, the following trends were confirmed:
- Proliferation promotion tendency in keratinocytes and fibroblasts (approx. 70% or more)
- Increased expression of barrier-related genes (profilaggrin) (approx. 160%)
- Promotion of hyaluronic acid production
- Suppression tendency of inflammation-related factors (COX-2, PGE2, IL-6)
Additionally, in case observations, the following were suggested:
- Tendency to improve barrier function and moisturizing state in the skin area
- Reduction of inflammatory tendencies
- Tendency to improve hair density and hair diameter in the scalp area
- Tendency to reduce hair loss
These results suggest the possibility that Minexin® acts not as a single function but as a multifaceted approach that works on the entire environment of the skin and scalp.
Based on the findings obtained in this research, Minexin® is expected to be utilized as a new approach in the anti-aging field and cosmetic medicine in the future.
Furthermore, further studies regarding its affinity with the cell-free domain are planned to proceed.
◼️ Presenter's Comment
Dr. Sawako Hibino
'Skin and scalp troubles do not occur due to a single cause but due to a combination of multiple factors. In this presentation, we examined the potential of an approach that focuses on that "entire environment." We intend to continue further verification from a clinical perspective in the future.'
◼️ Company Comment
flowli LLC
'We feel it is deeply meaningful to have been able to widely share the knowledge of basic and clinical observations regarding Minexin® through this academic conference presentation. We will continue product development and information dissemination based on evidence.'
◼️ Dr. Sawako Hibino
General Director, Medical Corporation Koshikai SAWAKO CLINIC x YS
Specially Appointed Associate Professor, Endowed Chair of Future Medical Science, Graduate School of Medicine, Osaka University
Representative Director, International Medical Science Research Society; President, Japan Society of Cosmetic Medicine
Councilor of the Japanese Society for Regenerative Medicine, Certified Physician of the Japanese Society for Regenerative Medicine, Specialist of the Japanese Society of Anti-Aging Medicine. She has served as a Lecturer at the Anti-Aging Research Center of Doshisha University, an Associate Professor at the Faculty of Health and Medical Sciences of Morinomiya University of Medical Sciences, and the Head of the Anti-Aging Medical Science Research Laboratory in the Basic Research Department of the Louis Pasteur Center for Medical Research.
Currently, as a pioneer in anti-aging medicine, she actively engages in advanced medicine, including the latest regenerative medicine, ranging from basic research to clinical research, and is internationally active. She has also garnered attention in media such as television and magazines.
Co-sponsored seminar exhibition venue
◼️ Japan Society of Cosmetic Medicine
The Japan Society of Cosmetic Medicine is an academic organization aimed at researching and disseminating information about cosmetics from a medical perspective based on scientific evidence. With an eye toward improving the QOL of the elderly and applying it to the medical and rehabilitation fields, it works toward the development of the cosmetic medicine field through academic meetings, educational activities, and the establishment of specialized qualification systems.
◼️ PHARMOLOGY Product Introduction
Epiderm Cryo Gel
Intensive Barrier Fix
Nutribalance: White Tab.
Skin Reset Drop
'PHARMOLOGY' is a skincare and haircare line formulated with 'Minexin', a proprietary ingredient born from research applying 10 types of natural minerals and patented technology.