[New Release June 12, 2026] Next-Generation Supplement with NMNH (Reduced NMN)

Mirai Lab BioScience Co., Ltd. [Headquarters: Chuo-ku, Tokyo; Representative Director: Nobuaki Shimizu] will begin selling 'NMNH LX,' an oral supplement containing 'Reduced β-Nicotinamide Mononucleotide (β-NMNH),' the reduced form of 'β-Nicotinamide Mononucleotide (β-NMN),' at a price of 540,000 yen (tax included) from Friday, June 12, 2026. (Please also check the '■ About Sales Shops' section below for details on the sales start date.) This product was developed by introducing a new perspective of 'balancing the entire internal environment,' rather than being bound solely by the conventional idea of 'supplementing what is lacking.' NMN is a rational answer to the approach of replenishing NAD⁺, which becomes deficient in cells with aging (Reference 1). On the other hand, NMNH is another new answer that emerged from the question of how to maintain a state of balance. ■ A New Idea Focusing Not Only on 'Deficiency' but Also on 'Imbalance' Until now, anti-aging care through oral supplements has primarily revolved around the methodology of 'supplementing' components that decrease with age. However, biological systems are not governed solely by simple addition and subtraction. It is important to consider not only 'how much of a specific component exists' but also 'in what state it exists.' Mirai Lab has reframed age-related changes not merely as 'deficiencies' but as 'accumulated imbalances' that arise during the process of the biological system adapting to its environment. ■ What is NMNH? NMNH is a molecule that is the reduced form of NMN. The dynamics of the oxidized form NAD⁺ and the reduced form NADH interconverting are fundamentally involved in cellular energy metabolism. NAD⁺ is like a container, and NADH is the container with contents (energy) inside. NADH can be likened to a 'charged battery,' and NAD⁺ to a 'discharged battery.' What is important here is to have a perspective not only on 'how much' of the energy carriers (NAD⁺ and NADH) exist, but also on 'which state' they exist in. Just as NMN is converted to NAD⁺ (discharged battery) within the cell, NMNH is converted to NADH (charged battery). Differences in molecular structure between NMN and NMNH ■ Research and Development Started in 2021 In 2021, a research group from the University of Amsterdam (Netherlands) published a research paper suggesting that NMNH may increase intracellular NAD⁺ levels more efficiently than NMN (Reference 2). At that time, the Mirai Lab research institute in Nihombashi, Tokyo, was interested not only in the change that increases NAD⁺ levels but also in the structural characteristics of the NMNH molecule. This was because the analogy between the 'NAD⁺ and NADH' relationship, which is fundamental to cellular energy metabolism, and the 'NMN and NMNH' relationship could be inferred from their respective molecular structures. ■ Commitment to Quality and Safety Mirai Lab conducted various quality checks in collaboration with external organizations to commercialize the NMNH-containing supplement. Multi-faceted checks including body composition, physique indices, vital sign measurements, urinalysis, and blood tests were performed, and the results are stored as quality control documentation. Furthermore, the product is manufactured under a strict quality control system, including production at a domestic GMP-compliant factory. ■ Recommended for ・Those who have been continuously taking NMN ・Those interested in new health approaches beyond just 'supplementing quantity' ・Those who want to be conscious of their daily lifestyle rhythm and internal environment balance ・Those who are aware of their changing condition with age ・Those looking to review their daily health habits ■ References 1. https://pubmed.ncbi.nlm.nih.gov/29514064/ 2. https://pubmed.ncbi.nlm.nih.gov/33724555/ ■ Product Overview Product Name: NMNH LX Sales Price: 540,000 yen (tax included) Release Date: Friday, June 12, 2026 Nihombashi Mitsukoshi Main Store: Wednesday, July 1, 2026, 0:00 Official Online Shop: Wednesday, July 1, 2026, 11:00 Directly Managed Store: MIRAILAB Wellness Branch Contents: 9.27 g (309 mg x 30 capsules) Country of Origin: Japan Nutritional Information (per capsule 309 mg): Energy 0.75 kcal / Protein 0.07 g / Fat 0.01 g / Carbohydrate 0.10 g / Salt Equivalent 0.05 g Ingredients: Reduced β-Nicotinamide Mononucleotide (NMNH) (domestically manufactured), Starch, Starch Decomposite / HPMC, Sucrose Fatty Acid Ester, Fine Silicon Dioxide Directions for Use: Take 1 capsule daily with water or lukewarm water. Storage Method: Store in a cool place away from high temperature, humidity, and direct sunlight. Precautions: ・Do not take if you have allergies after checking the ingredients. In rare cases, it may not suit your body depending on your physical condition or constitution. In that case, discontinue use. ・If you are taking medication or visiting a hospital, consult your doctor before taking. ・This product does not cure diseases or promote health through excessive intake. Please adhere to the recommended daily intake. ・Keep out of reach of infants and young children. ・Consume promptly after opening the individual package. ■ About Sales Shops The product is available at the following shops: 1) Friday, June 12, 2026 Nihombashi Mitsukoshi Main Store, Main Building 5F, Relaxing Laboratory / Promotion (Mirai Lab) Address: 1-4-1 Nihombashi Muromachi, Chuo-ku, Tokyo 103-8001 Phone: 03-3241-3311 (Main) https://www.mistore.jp/store/nihombashi/access.html *End date is undecided. *Please check the Nihombashi Mitsukoshi Main Store website for the latest information on business hours, business days, and event status before visiting. 2) From Wednesday, July 1, 2026, 0:00 (Scheduled) Mirai Lab Official Online Shop https://mirai-lab.jpn.com/ 3) From Wednesday, July 1, 2026, 11:00 (Scheduled) Directly Managed Store: MIRAILAB Wellness Branch Address: 1F, Dai-san Ginza Yamato Building, 2-11-10 Ginza, Chuo-ku, Tokyo 104-0061 Phone: 03-6243-3082 https://www.mirailab-bio.com/mirailabwellnessbranch/ ■ About Mirai Lab BioScience Mirai Lab BioScience, guided by the brand philosophy 'Luxury of Science,' operates a life science business that explores the ideals of beauty and health originating from life sciences.