In recent years, Akkermansia has gained significant attention as a representative next-generation probiotic, with numerous studies reporting its associations with gut barrier function, metabolic improvement, weight management, and immune regulation. AKK PROBIO® is a human gut-derived Akkermansia muciniphila strain developed through rigorous selection from over 200 candidate strains.
With this NDI notification completion, the manufacturing process, quality control system, safety testing, and scientific data for AKK PROBIO® have been reviewed by the FDA, and no safety concerns were raised. This represents a critical achievement confirming the quality and safety of AKK PROBIO®. It further strengthens credibility and regulatory readiness in the North American market, enabling expanded supply of scientifically backed Akkermansia ingredients to global brands and product developers.
In Japan’s health food market, demands for ingredient safety are increasing, making "proof of ingredient safety" a key criterion in material selection. In this context, achievements such as Self-GRAS status and NDI notification completion are highly valued as strong indicators of third-party, science-based safety evaluation. These accomplishments not only support product development for the U.S. market but also enhance product design and quality assurance systems for domestic and international business expansion, increasing trust among supplement manufacturers and OEM companies in ingredient adoption.
Functional Benefits of AKK PROBIO®
Akkermansia is recognized as a next-generation probiotic, often referred to as the "slimming bacterium" in TV and social media due to its roles in improving gut health and promoting GLP-1 secretion. AKK PROBIO® is a carefully selected strain from 200 candidates. Clinical trials involving 160 participants have confirmed that the heat-killed (inactive) form increases GLP-1 secretion by approximately 20%, while the live strain reduces body fat by about 1 kg. Multiple functional benefits have also been observed, including enhanced gut barrier integrity, metabolic improvement, immune modulation, and mental health support.
- Human gut-derived Akkermansia selected from 200 strains
- Supported by 13 peer-reviewed scientific publications (including 7 human clinical trials)
- Promotes GLP-1 and PYY production
- Supports weight, body fat, waist circumference, and BMI management
※ Ingredient source: [Barbar, Health Food Ingredient Search Site]
Microfood Co., Ltd. Product Lineup
[Main Product Specifications]
Product Name
AKK PROBIO (Live Strain)
AKK PROBIO (Heat-Killed)
Cell Count Specification
200 billion AUF/g
200 billion n-AFU/g
Packaging
1kg/aluminum pouch
1kg/aluminum pouch
Microfood Co., Ltd.
Microfood Co., Ltd. was an early adopter of AKK PROBIO®, serving as the exclusive distributor in Japan. The company maintains domestic inventory and supplies both live and heat-killed forms of Akkermansia as food ingredients. Leveraging over 20 years of expertise in probiotic materials, Microfood supports flexible formulation design tailored to customer needs and contributes to the widespread adoption and market development of Akkermansia.
Yusuke Hamada, Representative Director
Website: https://www.microfood.co.jp
Partner Company (NatureLab. NUTRITION)
Microfood collaborates with NatureLab. NUTRITION for marketing in the Japanese market.
NatureLab. NUTRITION is an ingredient trading company specializing in raw materials and formulation development for dietary supplements, sports nutrition, and functional foods. Utilizing a global network, it delivers high-value ingredients and product development support, with strengths in innovative material proposals and reliable quality assurance, enhancing brand competitiveness.
NatureLab. NUTRITION
Website: https://www.naturelabnutrition.com/
Contact Information
Microfood Co., Ltd.
Representative Director: Yusuke Hamada
TEL: 080-5029-2629
Email: yusuke.hamada@microfood.co.jp
FACT BOX
- Source: PR TIMES
- Category: New Product
- Organizations: NatureLab. NUTRITION